(1R,8R)-10,12-dimethoxy-13-(4-methoxybenzyl)-3,4,7,8-tetrahydro-8,1-(epiminomethano)benzo[g][1,5]oxathiecine-5,14(1H)-dione

Base Information

Chemical Name:(1R,8R)-10,12-dimethoxy-13-(4-methoxybenzyl)-3,4,7,8-tetrahydro-8,1-(epiminomethano)benzo[g][1,5]oxathiecine-5,14(1H)-dione
CAS No.:1339232-14-2
Molecular Formula:C₂₃H₂₅NO₆S
Molecular Weight:443.521
Hs Code.:

Synonyms:(1R,8R)-10,12-dimethoxy-13-(4-methoxybenzyl)-3,4,7,8-tetrahydro-8,1-(epiminomethano)benzo[g][1,5]oxathiecine-5,14(1H)-dione

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Chemical Property of (1R,8R)-10,12-dimethoxy-13-(4-methoxybenzyl)-3,4,7,8-tetrahydro-8,1-(epiminomethano)benzo[g][1,5]oxathiecine-5,14(1H)-dione

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Technology Process of (1R,8R)-10,12-dimethoxy-13-(4-methoxybenzyl)-3,4,7,8-tetrahydro-8,1-(epiminomethano)benzo[g][1,5]oxathiecine-5,14(1H)-dione

There total 2 articles about (1R,8R)-10,12-dimethoxy-13-(4-methoxybenzyl)-3,4,7,8-tetrahydro-8,1-(epiminomethano)benzo[g][1,5]oxathiecine-5,14(1H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1339232-11-9
3-(((1R,4R)-1-(hydroxymethyl)-5,7-dimethoxy-2-(4-methoxybenzyl)-3-oxo-1,2,3,4-tetrahydroisoquinolin-4-yl)thio)propanoic acid

: 1339232-14-2
(1R,8R)-10,12-dimethoxy-13-(4-methoxybenzyl)-3,4,7,8-tetrahydro-8,1-(epiminomethano)benzo[g][1,5]oxathiecine-5,14(1H)-dione

Guidance literature:: With dmap; 2-methyl-6-nitrobenzoic anhydride; In dichloromethane; at 20 ℃; for 6h; Inert atmosphere;
DOI:10.1039/c1cc13992d

Reference yield:

: methyl 3-(((1R)-1-(hydroxymethyl)-5,7-dimethoxy-2-(4-methoxybenzyl)-3-oxo-1,2,3,4-tetrahydroisoquinolin-4-yl)thio)propanoate

: 1339232-14-2
(1R,8R)-10,12-dimethoxy-13-(4-methoxybenzyl)-3,4,7,8-tetrahydro-8,1-(epiminomethano)benzo[g][1,5]oxathiecine-5,14(1H)-dione

Guidance literature:: Multi-step reaction with 2 steps

1: lithium hydroxide monohydrate / tetrahydrofuran / 18 h / 20 °C / Inert atmosphere

2: dmap; 2-methyl-6-nitrobenzoic anhydride / dichloromethane / 6 h / 20 °C / Inert atmosphere

With dmap; lithium hydroxide monohydrate; 2-methyl-6-nitrobenzoic anhydride; In tetrahydrofuran; dichloromethane; 2: Pummerer type cyclisation;
DOI:10.1039/c1cc13992d