5-[[4-[2-(4-ethylphenyl)-2-oxoethoxy]phenyl]methyl]-2,4-thiazolidinedione

Base Information

Chemical Name:5-[[4-[2-(4-ethylphenyl)-2-oxoethoxy]phenyl]methyl]-2,4-thiazolidinedione
CAS No.:1245699-68-6
Molecular Formula:C₂₀H₁₉NO₄S
Molecular Weight:369.441
Hs Code.:

Synonyms:5-[[4-[2-(4-ethylphenyl)-2-oxoethoxy]phenyl]methyl]-2,4-thiazolidinedione

Suppliers and Price of 5-[[4-[2-(4-ethylphenyl)-2-oxoethoxy]phenyl]methyl]-2,4-thiazolidinedione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 5-[[4-[2-(4-ethylphenyl)-2-oxoethoxy]phenyl]methyl]-2,4-thiazolidinedione

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 5-[[4-[2-(4-ethylphenyl)-2-oxoethoxy]phenyl]methyl]-2,4-thiazolidinedione

There total 5 articles about 5-[[4-[2-(4-ethylphenyl)-2-oxoethoxy]phenyl]methyl]-2,4-thiazolidinedione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1245699-67-5
5-[[4-[2-(4-ethylphenyl)-2-hydroxyethoxy]phenyl]methyl]-2,4-thiazolidinedione

: 1245699-68-6
5-[[4-[2-(4-ethylphenyl)-2-oxoethoxy]phenyl]methyl]-2,4-thiazolidinedione

Guidance literature:: 5-[[4-[2-(4-ethylphenyl)-2-hydroxyethoxy]phenyl]methyl]-2,4-thiazolidinedione; With phosphorus pentoxide; In dichloromethane; dimethyl sulfoxide; for 0.25h; Inert atmosphere;

With N-ethyl-N,N-diisopropylamine; In dichloromethane; dimethyl sulfoxide; for 1h; Inert atmosphere;
DOI:10.1016/j.bmc.2018.10.033

Reference yield:

: 5-[[4-[2-(4-ethylphenyl)-2-oxoethoxy]phenyl]methylene]-2,4-thiazolidinedione

: 1245699-68-6
5-[[4-[2-(4-ethylphenyl)-2-oxoethoxy]phenyl]methyl]-2,4-thiazolidinedione

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide; sodium tetrahydroborate; [2,2]bipyridinyl; cobalt(II) chloride hexahydrate / tetrahydrofuran; water; N,N-dimethyl-formamide / 18.5 h / 20 °C

2.1: phosphorus pentoxide / dichloromethane; dimethyl sulfoxide / 0.25 h / Inert atmosphere

2.2: 1 h / Inert atmosphere

With [2,2]bipyridinyl; sodium tetrahydroborate; cobalt(II) chloride hexahydrate; phosphorus pentoxide; sodium hydroxide; In tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2018.10.033

Reference yield:

: 937-30-4
4-ethylacetophenone

: 1245699-68-6
5-[[4-[2-(4-ethylphenyl)-2-oxoethoxy]phenyl]methyl]-2,4-thiazolidinedione

Guidance literature:: Multi-step reaction with 5 steps

1.1: toluene-4-sulfonic acid; N-Bromosuccinimide / acetonitrile / 2 h / Reflux; Inert atmosphere

2.1: potassium carbonate / acetone / 20 °C

3.1: piperidine / ethanol / 12 h / Reflux; Inert atmosphere

4.1: sodium hydroxide; sodium tetrahydroborate; [2,2]bipyridinyl; cobalt(II) chloride hexahydrate / tetrahydrofuran; water; N,N-dimethyl-formamide / 18.5 h / 20 °C

5.1: phosphorus pentoxide / dichloromethane; dimethyl sulfoxide / 0.25 h / Inert atmosphere

5.2: 1 h / Inert atmosphere

With piperidine; [2,2]bipyridinyl; sodium tetrahydroborate; N-Bromosuccinimide; cobalt(II) chloride hexahydrate; phosphorus pentoxide; potassium carbonate; toluene-4-sulfonic acid; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone; acetonitrile; 3.1: |Knoevenagel Condensation;
DOI:10.1016/j.bmc.2018.10.033