(S)-2-Benzyloxycarbonylamino-5-methylene-hexanedioic acid 1-benzyl ester 6-ethyl ester

Base Information

Chemical Name:(S)-2-Benzyloxycarbonylamino-5-methylene-hexanedioic acid 1-benzyl ester 6-ethyl ester
CAS No.:115573-30-3
Molecular Formula:C₂₄H₂₇NO₆
Molecular Weight:425.481
Hs Code.:

Synonyms:(S)-2-Benzyloxycarbonylamino-5-methylene-hexanedioic acid 1-benzyl ester 6-ethyl ester

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Chemical Property of (S)-2-Benzyloxycarbonylamino-5-methylene-hexanedioic acid 1-benzyl ester 6-ethyl ester

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Technology Process of (S)-2-Benzyloxycarbonylamino-5-methylene-hexanedioic acid 1-benzyl ester 6-ethyl ester

There total 4 articles about (S)-2-Benzyloxycarbonylamino-5-methylene-hexanedioic acid 1-benzyl ester 6-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 65926-39-8
(R)-benzyl 2-(((benzyloxy)carbonyl)amino)-3-iodopropanoate

: 17435-72-2
ethyl 2-bromomethyl-2-propenoate

: 115573-30-3
(S)-2-Benzyloxycarbonylamino-5-methylene-hexanedioic acid 1-benzyl ester 6-ethyl ester

Guidance literature:: (R)-benzyl 2-(((benzyloxy)carbonyl)amino)-3-iodopropanoate; With zinc; In N,N-dimethyl-formamide; at 20 ℃; for 0.333333h;

ethyl 2-bromomethyl-2-propenoate; In N,N-dimethyl-formamide; Further stages.;
DOI:10.1016/j.tetlet.2004.09.033

Reference yield: 61.0%

: 108286-71-1
ethyl-2-tributylstannylmethyl acrylate

: 65926-39-8
(R)-benzyl 2-(((benzyloxy)carbonyl)amino)-3-iodopropanoate

: 115573-30-3
(S)-2-Benzyloxycarbonylamino-5-methylene-hexanedioic acid 1-benzyl ester 6-ethyl ester

Guidance literature:: With 2,2'-azobis(isobutyronitrile); In toluene; at 65 - 70 ℃;
DOI:10.1016/j.tetlet.2004.09.033

Reference yield:

: 4779-31-1
Z-Asp-OBn

: 115573-30-3
(S)-2-Benzyloxycarbonylamino-5-methylene-hexanedioic acid 1-benzyl ester 6-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1) N-methyl morpholine, isobutyl chloroformate, 2) triethylamine / 1) THF, -15 deg C, 5 min, 2) THF, -15 deg C, 45 min, in the dark

2: 0.33 h / Ambient temperature; Irradiation

With 4-methyl-morpholine; triethylamine; isobutyl chloroformate;
DOI:10.1016/S0040-4020(01)90305-9