tert-butyl N-(4-{4-oxo-2-[4'-(trifluoromethoxy)biphenyl-3-yl]butyl}benzoyl)-β-alaninate

Base Information

Chemical Name:tert-butyl N-(4-{4-oxo-2-[4'-(trifluoromethoxy)biphenyl-3-yl]butyl}benzoyl)-β-alaninate
CAS No.:910819-16-8
Molecular Formula:C₃₁H₃₂F₃NO₅
Molecular Weight:555.594
Hs Code.:

Synonyms:tert-butyl N-(4-{4-oxo-2-[4'-(trifluoromethoxy)biphenyl-3-yl]butyl}benzoyl)-β-alaninate

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Chemical Property of tert-butyl N-(4-{4-oxo-2-[4'-(trifluoromethoxy)biphenyl-3-yl]butyl}benzoyl)-β-alaninate

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Technology Process of tert-butyl N-(4-{4-oxo-2-[4'-(trifluoromethoxy)biphenyl-3-yl]butyl}benzoyl)-β-alaninate

There total 3 articles about tert-butyl N-(4-{4-oxo-2-[4'-(trifluoromethoxy)biphenyl-3-yl]butyl}benzoyl)-β-alaninate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 910819-13-5
tert-butyl N-(4-iodobenzoyl)-β-alaninate

: 910819-15-7
3-[4'-(trifluoromethoxy)biphenyl-3-yl]but-3-en-1-ol

: 910819-16-8
tert-butyl N-(4-{4-oxo-2-[4'-(trifluoromethoxy)biphenyl-3-yl]butyl}benzoyl)-β-alaninate

Guidance literature:: With lithium acetate; tetrabutyl-ammonium chloride; lithium chloride; palladium diacetate; In N,N-dimethyl-formamide; at 90 ℃;

Reference yield:

: 910819-14-6
3-(3-chlorophenyl)but-3-en-1-ol

: 910819-16-8
tert-butyl N-(4-{4-oxo-2-[4'-(trifluoromethoxy)biphenyl-3-yl]butyl}benzoyl)-β-alaninate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium phosphate / palladium diacetate; CyJohnPhos / toluene / 1 h / 100 °C

2: lithium acetate; tetrabutyl-ammonium chloride; lithium chloride / palladium diacetate / N,N-dimethyl-formamide / 90 °C

With potassium phosphate; lithium acetate; tetrabutyl-ammonium chloride; lithium chloride; palladium diacetate; CyJohnPhos; In N,N-dimethyl-formamide; toluene; 1: Suzuki Coupling;

Reference yield:

: 63503-60-6
3-chlorophenylboronic acid

: 910819-16-8
tert-butyl N-(4-{4-oxo-2-[4'-(trifluoromethoxy)biphenyl-3-yl]butyl}benzoyl)-β-alaninate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 3 h / Heating / reflux

2: potassium phosphate / palladium diacetate; CyJohnPhos / toluene / 1 h / 100 °C

3: lithium acetate; tetrabutyl-ammonium chloride; lithium chloride / palladium diacetate / N,N-dimethyl-formamide / 90 °C

With potassium phosphate; lithium acetate; tetrabutyl-ammonium chloride; sodium carbonate; lithium chloride; palladium diacetate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; CyJohnPhos; In 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; toluene; 1: Suzuki Coupling / 2: Suzuki Coupling;