4'-methyl-N-((6-methylpyridin-3-yl)methyl)-5-(oxiran-2-yl)biphenyl-3-carboxamide

Base Information

Chemical Name:4'-methyl-N-((6-methylpyridin-3-yl)methyl)-5-(oxiran-2-yl)biphenyl-3-carboxamide
CAS No.:1186519-40-3
Molecular Formula:C₂₃H₂₂N₂O₂
Molecular Weight:358.44
Hs Code.:

Synonyms:4'-methyl-N-((6-methylpyridin-3-yl)methyl)-5-(oxiran-2-yl)biphenyl-3-carboxamide

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Chemical Property of 4'-methyl-N-((6-methylpyridin-3-yl)methyl)-5-(oxiran-2-yl)biphenyl-3-carboxamide

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Technology Process of 4'-methyl-N-((6-methylpyridin-3-yl)methyl)-5-(oxiran-2-yl)biphenyl-3-carboxamide

There total 3 articles about 4'-methyl-N-((6-methylpyridin-3-yl)methyl)-5-(oxiran-2-yl)biphenyl-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1186519-39-0
5-formyl-4'-methyl-N-((6-methylpyridin-3-yl)methyl)biphenyl-3-carboxamide

: trimethylsulfoxonium iodide

: 1186519-40-3
4'-methyl-N-((6-methylpyridin-3-yl)methyl)-5-(oxiran-2-yl)biphenyl-3-carboxamide

Guidance literature:: trimethylsulfoxonium iodide; With sodium hydride; In dimethyl sulfoxide; at -10 - 20 ℃;

5-formyl-4'-methyl-N-((6-methylpyridin-3-yl)methyl)biphenyl-3-carboxamide; In dimethyl sulfoxide; at 0 - 20 ℃;

Reference yield:

: 619-21-6
m-formylphenyl benzoic acid

: 1186519-40-3
4'-methyl-N-((6-methylpyridin-3-yl)methyl)-5-(oxiran-2-yl)biphenyl-3-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-Bromosuccinimide; sulfuric acid / 3.17 h / 20 °C

2.1: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; toluene / 5 h / Reflux

3.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 2 h / 60 °C

4.1: sodium hydride / dimethyl sulfoxide / -10 - 20 °C

4.2: 0 - 20 °C

With N-Bromosuccinimide; sulfuric acid; sodium hydride; caesium carbonate; N-ethyl-N,N-diisopropylamine; HATU; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;

Reference yield:

: 398119-27-2
3-bromo-5-formylbenzoic acid

: 1186519-40-3
4'-methyl-N-((6-methylpyridin-3-yl)methyl)-5-(oxiran-2-yl)biphenyl-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; toluene / 5 h / Reflux

2.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 2 h / 60 °C

3.1: sodium hydride / dimethyl sulfoxide / -10 - 20 °C

3.2: 0 - 20 °C

With sodium hydride; caesium carbonate; N-ethyl-N,N-diisopropylamine; HATU; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;