4-[3-(hydroxymethyl)-1-pyrrolidinyl]-N-methyl-3-(1H-purin-6-ylamino)benzenesuIfonamide

Base Information

Chemical Name:4-[3-(hydroxymethyl)-1-pyrrolidinyl]-N-methyl-3-(1H-purin-6-ylamino)benzenesuIfonamide
CAS No.:1351088-58-8
Molecular Formula:C₁₇H₂₁N₇O₃S
Molecular Weight:403.465
Hs Code.:

Synonyms:4-[3-(hydroxymethyl)-1-pyrrolidinyl]-N-methyl-3-(1H-purin-6-ylamino)benzenesuIfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-[3-(hydroxymethyl)-1-pyrrolidinyl]-N-methyl-3-(1H-purin-6-ylamino)benzenesuIfonamide

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Technology Process of 4-[3-(hydroxymethyl)-1-pyrrolidinyl]-N-methyl-3-(1H-purin-6-ylamino)benzenesuIfonamide

There total 5 articles about 4-[3-(hydroxymethyl)-1-pyrrolidinyl]-N-methyl-3-(1H-purin-6-ylamino)benzenesuIfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

: 85310-69-6,110013-18-8,110013-19-9,5082-74-6
pyrrolidin-3-ylmethanol

: 1351087-88-1
4-fluoro-N-methyl-3-(9H-purin-6-ylamino)benzenesulfonamide

: 1351088-58-8
4-[3-(hydroxymethyl)-1-pyrrolidinyl]-N-methyl-3-(1H-purin-6-ylamino)benzenesuIfonamide

Guidance literature:: In 1-methyl-pyrrolidin-2-one; at 110 ℃; for 18h; Sealed vessel;

Reference yield:

: 1493-27-2,127723-77-7
ortho-nitrofluorobenzene

: 1351088-58-8
4-[3-(hydroxymethyl)-1-pyrrolidinyl]-N-methyl-3-(1H-purin-6-ylamino)benzenesuIfonamide

Guidance literature:: Multi-step reaction with 5 steps

1: chlorosulfonic acid / 18 h / 100 °C

2: triethylamine / tetrahydrofuran / 1 h / -35 °C

3: hydrogen / palladium / tetrahydrofuran / 50 °C / Inert atmosphere

4: silver trifluoromethanesulfonate / N,N-dimethyl-formamide / 20 h / 80 °C / Microwave irradiation; Sealed tube

5: 1-methyl-pyrrolidin-2-one / 18 h / 110 °C / Sealed vessel

With chlorosulfonic acid; hydrogen; silver trifluoromethanesulfonate; triethylamine; palladium; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide;

Reference yield:

: 6668-56-0
4-fluoro-3-nitrobenzene-1-sulfonyl chloride

: 1351088-58-8
4-[3-(hydroxymethyl)-1-pyrrolidinyl]-N-methyl-3-(1H-purin-6-ylamino)benzenesuIfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / tetrahydrofuran / 1 h / -35 °C

2: hydrogen / palladium / tetrahydrofuran / 50 °C / Inert atmosphere

3: silver trifluoromethanesulfonate / N,N-dimethyl-formamide / 20 h / 80 °C / Microwave irradiation; Sealed tube

4: 1-methyl-pyrrolidin-2-one / 18 h / 110 °C / Sealed vessel

With hydrogen; silver trifluoromethanesulfonate; triethylamine; palladium; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide;