[(2S)-2-Amino-3-phenylpropyl]diphenylphosphine

Base Information

Chemical Name:[(2S)-2-Amino-3-phenylpropyl]diphenylphosphine
CAS No.:146476-38-2
Molecular Formula:C₂₁H₂₂NP
Molecular Weight:319.386
Hs Code.:
DSSTox Substance ID:DTXSID001224930
Nikkaji Number:J967.724K
Mol file:146476-38-2.mol

Synonyms:146476-38-2;[(2S)-2-Amino-3-phenylpropyl]diphenylphosphine;(2S)-1-diphenylphosphanyl-3-phenylpropan-2-amine;(alphaS)-alpha-[(Diphenylphosphino)methyl]benzeneethanamine;(S)-1-(Diphenylphosphanyl)-3-phenylpropan-2-amine;(|AS)-|A-[(Diphenylphosphino)methyl]benzeneethanamine;DTXSID001224930;CS-0088004

Suppliers and Price of [(2S)-2-Amino-3-phenylpropyl]diphenylphosphine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of [(2S)-2-Amino-3-phenylpropyl]diphenylphosphine

Chemical Property:

Boiling Point:460.8±38.0 °C(Predicted)
PKA:8.87±0.10(Predicted)
XLogP3:4.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:6
Exact Mass:319.148986704
Heavy Atom Count:23
Complexity:296

Purity/Quality:: 95%-98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC=C(C=C1)CC(CP(C2=CC=CC=C2)C3=CC=CC=C3)N
Isomeric SMILES:C1=CC=C(C=C1)C[C@@H](CP(C2=CC=CC=C2)C3=CC=CC=C3)N

Technology Process of [(2S)-2-Amino-3-phenylpropyl]diphenylphosphine

There total 8 articles about [(2S)-2-Amino-3-phenylpropyl]diphenylphosphine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 146476-36-0
tert-butyl (S)-(1-(diphenylphosphanyl)-3-phenylpropan-2-yl)carbamate

: 146476-38-2,1103534-03-7
(S)-1-(diphenylphosphino)-3-phenylpropan-2-amine

Guidance literature:: With trifluoroacetic acid;
DOI:10.1246/cl.1992.2409

Reference yield:

: 66605-57-0
(S)-N-tert-butoxycarbonyl-2-amino-3-phenylpropanol

: 146476-38-2,1103534-03-7
(S)-1-(diphenylphosphino)-3-phenylpropan-2-amine

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / 0 °C

2: n-BuLi / tetrahydrofuran / -20 °C

3: CF₃COOH

With pyridine; n-butyllithium; trifluoroacetic acid; In tetrahydrofuran;
DOI:10.1246/cl.1992.2409

Reference yield:

: 3182-95-4
L-Phenylalaninol

: 146476-38-2,1103534-03-7
(S)-1-(diphenylphosphino)-3-phenylpropan-2-amine

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere; Glovebox; Schlenk technique

2: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere; Glovebox; Schlenk technique

3: tetrahydrofuran / 16 h / -40 - 20 °C / Inert atmosphere; Glovebox; Schlenk technique

4: trifluoroacetic acid / dichloromethane / 15 h / 0 - 20 °C / Inert atmosphere; Glovebox; Schlenk technique

With triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1021/om5008083