(Z)-1-((4-chlorophenyl)ethynyl)-2-(2,3-dimethylbut-1-en-1-yl)benzene

Base Information

• Chemical Name: (Z)-1-((4-chlorophenyl)ethynyl)-2-(2,3-dimethylbut-1-en-1-yl)benzene
• CAS No.: 1398121-17-9
• Molecular Formula: C₂₀H₁₉Cl
• Molecular Weight: 294.824
• Mol file: 1398121-17-9.mol

Synonyms:(Z)-1-((4-chlorophenyl)ethynyl)-2-(2,3-dimethylbut-1-en-1-yl)benzene

Chemical Property of (Z)-1-((4-chlorophenyl)ethynyl)-2-(2,3-dimethylbut-1-en-1-yl)benzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (Z)-1-((4-chlorophenyl)ethynyl)-2-(2,3-dimethylbut-1-en-1-yl)benzene

There total 3 articles about (Z)-1-((4-chlorophenyl)ethynyl)-2-(2,3-dimethylbut-1-en-1-yl)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-n-chlorophenylacetylene (873-73-4) + C12H15I (1398121-59-9) → (E)-1-((4-chlorophenyl)ethynyl)-2-(2,3-dimethylbut-1-en-1-yl)benzene (1398121-16-8) + (Z)-1-((4-chlorophenyl)ethynyl)-2-(2,3-dimethylbut-1-en-1-yl)benzene (1398121-17-9)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; diethylamine; In N,N-dimethyl-formamide; at 20 ℃; Overall yield = 97 %; Inert atmosphere;

DOI:10.1021/ol3020682 DOI:10.1021/ol3020682

Reference yield:

3-methyl-butan-2-one (563-80-4) → (E)-1-((4-chlorophenyl)ethynyl)-2-(2,3-dimethylbut-1-en-1-yl)benzene (1398121-16-8) + (Z)-1-((4-chlorophenyl)ethynyl)-2-(2,3-dimethylbut-1-en-1-yl)benzene (1398121-17-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: lithium diisopropyl amide / tetrahydrofuran; hexane / 0 - 20 °C / Inert atmosphere

1.2: 20 °C / Inert atmosphere

2.1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; diethylamine / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; diethylamine; lithium diisopropyl amide; In tetrahydrofuran; hexane; N,N-dimethyl-formamide; 2.1: |Sonogashira Cross-Coupling;

DOI:10.1021/ol3020682 DOI:10.1021/ol3020682

Reference yield:

ethyl [(2-iodophenyl)methyl]phosphonate (62680-68-6) → (E)-1-((4-chlorophenyl)ethynyl)-2-(2,3-dimethylbut-1-en-1-yl)benzene (1398121-16-8) + (Z)-1-((4-chlorophenyl)ethynyl)-2-(2,3-dimethylbut-1-en-1-yl)benzene (1398121-17-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: lithium diisopropyl amide / tetrahydrofuran; hexane / 0 - 20 °C / Inert atmosphere

1.2: 20 °C / Inert atmosphere

2.1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; diethylamine / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; diethylamine; lithium diisopropyl amide; In tetrahydrofuran; hexane; N,N-dimethyl-formamide; 2.1: |Sonogashira Cross-Coupling;

DOI:10.1021/ol3020682 DOI:10.1021/ol3020682

upstream raw materials:

4-n-chlorophenylacetylene

C₁₂H₁₅I

ethyl [(2-iodophenyl)methyl]phosphonate

3-methyl-butan-2-one