N-(5-amino-1-(2,4-dimethoxybenzyl)-4-((4-hydroxyphenyl)diazenyl)-1H-pyrazol-3-yl)thiophene-2-carboxamide

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Chemical Name:N-(5-amino-1-(2,4-dimethoxybenzyl)-4-((4-hydroxyphenyl)diazenyl)-1H-pyrazol-3-yl)thiophene-2-carboxamide
CAS No.:1374431-96-5
Molecular Formula:C₂₃H₂₂N₆O₄S
Molecular Weight:478.531
Hs Code.:

Synonyms:N-(5-amino-1-(2,4-dimethoxybenzyl)-4-((4-hydroxyphenyl)diazenyl)-1H-pyrazol-3-yl)thiophene-2-carboxamide

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Chemical Property of N-(5-amino-1-(2,4-dimethoxybenzyl)-4-((4-hydroxyphenyl)diazenyl)-1H-pyrazol-3-yl)thiophene-2-carboxamide

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Technology Process of N-(5-amino-1-(2,4-dimethoxybenzyl)-4-((4-hydroxyphenyl)diazenyl)-1H-pyrazol-3-yl)thiophene-2-carboxamide

There total 3 articles about N-(5-amino-1-(2,4-dimethoxybenzyl)-4-((4-hydroxyphenyl)diazenyl)-1H-pyrazol-3-yl)thiophene-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 1374431-91-0
4-((5-amino-1-(2,4-dimethoxybenzyl)-3-(thiophene-2-carboxamido)-1H-pyrazol-4-yl)diazenyl)phenyl tert-butyl carbonate

: 1374431-96-5
N-(5-amino-1-(2,4-dimethoxybenzyl)-4-((4-hydroxyphenyl)diazenyl)-1H-pyrazol-3-yl)thiophene-2-carboxamide

Guidance literature:: 4-((5-amino-1-(2,4-dimethoxybenzyl)-3-(thiophene-2-carboxamido)-1H-pyrazol-4-yl)diazenyl)phenyl tert-butyl carbonate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

With ammonia; In water; at 20 ℃; for 2h; pH=10;
DOI:10.1016/j.tet.2012.03.063

Reference yield:

: 1374431-87-4
4-((3,5-diamino-1-(2,4-dimethoxybenzyl)-1H-pyrazol-4-yl)diazenyl)phenol

: 1374431-96-5
N-(5-amino-1-(2,4-dimethoxybenzyl)-4-((4-hydroxyphenyl)diazenyl)-1H-pyrazol-3-yl)thiophene-2-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine / 18 h / 2 - 20 °C

2.1: pyridine / dichloromethane / 18 h / 2 - 20 °C

3.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

3.2: 2 h / 20 °C / pH 10

With pyridine; trifluoroacetic acid; In dichloromethane;
DOI:10.1016/j.tet.2012.03.063

Reference yield:

: 1374431-88-5
tert-butyl (4-((3,5-diamino-1-(2,4-dimethoxybenzyl)-1H-pyrazol-4-yl)diazenyl)phenyl) carbonate

: 1374431-96-5
N-(5-amino-1-(2,4-dimethoxybenzyl)-4-((4-hydroxyphenyl)diazenyl)-1H-pyrazol-3-yl)thiophene-2-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: pyridine / dichloromethane / 18 h / 2 - 20 °C

2.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

2.2: 2 h / 20 °C / pH 10

With pyridine; trifluoroacetic acid; In dichloromethane;
DOI:10.1016/j.tet.2012.03.063