(1R,2S)-2-(dibenzylamino)-1-[ethoxy(oxido)phosphino]-4-methylpentyl acetate

Base Information

• Chemical Name: (1R,2S)-2-(dibenzylamino)-1-[ethoxy(oxido)phosphino]-4-methylpentyl acetate
• CAS No.: 441766-53-6
• Molecular Formula: C₂₄H₃₄NO₄P
• Molecular Weight: 431.512
• Mol file: 441766-53-6.mol

Synonyms:(1R,2S)-2-(dibenzylamino)-1-[ethoxy(oxido)phosphino]-4-methylpentyl acetate

Chemical Property of (1R,2S)-2-(dibenzylamino)-1-[ethoxy(oxido)phosphino]-4-methylpentyl acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,2S)-2-(dibenzylamino)-1-[ethoxy(oxido)phosphino]-4-methylpentyl acetate

There total 2 articles about (1R,2S)-2-(dibenzylamino)-1-[ethoxy(oxido)phosphino]-4-methylpentyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

acetic anhydride (108-24-7) + ethyl (1R,2S)-2-(dibenzylamino)-1-hydroxy-4-methylpentylphosphinate (366013-27-6) → (1R,2S)-2-(dibenzylamino)-1-[ethoxy(oxido)phosphino]-4-methylpentyl acetate (441766-53-6)

Guidance literature:

With pyridine; dmap; In dichloromethane; at 20 ℃;

DOI:10.1016/S0040-4020(02)00136-9

Reference yield:

(S)-2-(dibenzylamino)-4-methylpentanal (111060-65-2) → (1R,2S)-2-(dibenzylamino)-1-[ethoxy(oxido)phosphino]-4-methylpentyl acetate (441766-53-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 3 percent / (R)-ALB / tetrahydrofuran / 12 h / -40 °C

2: 95 percent / DMAP; pyridine / CH₂Cl₂ / 20 °C

With pyridine; dmap; Al-Li-(R,R')-2,2'-dihydroxy-1,1'-binaphthyl; In tetrahydrofuran; dichloromethane;

DOI:10.1016/S0040-4020(02)00136-9

Reference yield:

(1R,2S)-2-(dibenzylamino)-1-[ethoxy(oxido)phosphino]-4-methylpentyl acetate (441766-53-6) → Acetic acid (1R,2S)-2-dibenzylamino-4-methyl-1-phosphono-pentyl ester

Guidance literature:

(1R,2S)-2-(dibenzylamino)-1-[ethoxy(oxido)phosphino]-4-methylpentyl acetate; With iodine; dimethyl sulfoxide; In tetrahydrofuran; at 60 ℃;

With trimethylsilyl bromide; In dichloromethane; at 20 ℃;

With methanol; at 20 ℃;

DOI:10.1016/S0040-4020(02)00136-9

upstream raw materials:

acetic anhydride

ethyl (1R,2S)-2-(dibenzylamino)-1-hydroxy-4-methylpentylphosphinate

(S)-2-(dibenzylamino)-4-methylpentanal