C₃₃H₃₃F₃N₂O₇S

Base Information

• Chemical Name: C₃₃H₃₃F₃N₂O₇S
• CAS No.: 1374109-30-4
• Molecular Formula: C₃₃H₃₃F₃N₂O₇S
• Molecular Weight: 658.695
• Mol file: 1374109-30-4.mol

Synonyms:C₃₃H₃₃F₃N₂O₇S

Chemical Property of C₃₃H₃₃F₃N₂O₇S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₃H₃₃F₃N₂O₇S

There total 9 articles about C₃₃H₃₃F₃N₂O₇S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

3,4-dihydro-2H-pyran (110-87-2) + C28H25F3N2O6S (1374109-29-1) → C33H33F3N2O7S (1374109-30-4)

Guidance literature:

With toluene-4-sulfonic acid; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

quinoline-2,6-diol (19315-93-6) → C33H33F3N2O7S (1374109-30-4)

Guidance literature:

Multi-step reaction with 9 steps

1.1: thionyl chloride; N,N-dimethyl-formamide / 16 h / 20 °C / Cooling with ice

2.1: pyridinium p-toluenesulfonate / tetrahydrofuran / 2.5 h / 20 °C

3.1: potassium carbonate / water; 1,2-dimethoxyethane / 9 h / 80 °C / Inert atmosphere

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / Cooling with ice; Inert atmosphere

4.2: 0.17 h

5.1: trifluoroacetic acid / chloroform / 1 h / 20 °C / Cooling with ice

6.1: triethylamine / dichloromethane / 0.5 h / Cooling with ice

7.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 18.5 h / 20 °C / Cooling with ice

8.1: trifluoroacetic acid / chloroform; water / 72 h / 20 °C / Cooling with ice

9.1: toluene-4-sulfonic acid / dichloromethane / 1 h / 20 °C

With thionyl chloride; di-isopropyl azodicarboxylate; pyridinium p-toluenesulfonate; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; triethylamine; N,N-dimethyl-formamide; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; chloroform; water; N,N-dimethyl-formamide; mineral oil;

Reference yield:

6-hydroxy-2-chloroquinoline (577967-89-6) → C33H33F3N2O7S (1374109-30-4)

Guidance literature:

Multi-step reaction with 8 steps

1.1: pyridinium p-toluenesulfonate / tetrahydrofuran / 2.5 h / 20 °C

2.1: potassium carbonate / water; 1,2-dimethoxyethane / 9 h / 80 °C / Inert atmosphere

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / Cooling with ice; Inert atmosphere

3.2: 0.17 h

4.1: trifluoroacetic acid / chloroform / 1 h / 20 °C / Cooling with ice

5.1: triethylamine / dichloromethane / 0.5 h / Cooling with ice

6.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 18.5 h / 20 °C / Cooling with ice

7.1: trifluoroacetic acid / chloroform; water / 72 h / 20 °C / Cooling with ice

8.1: toluene-4-sulfonic acid / dichloromethane / 1 h / 20 °C

With di-isopropyl azodicarboxylate; pyridinium p-toluenesulfonate; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; triethylamine; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; chloroform; water; N,N-dimethyl-formamide; mineral oil;

upstream raw materials:

quinoline-2,6-diol

6-hydroxy-2-chloroquinoline

3,4-dihydro-2H-pyran

C₂₈H₂₅F₃N₂O₆S

Downstream raw materials:

2-(4-methylaminophenyl)-6-[[2-(tetrahydro-2H-pyran-2-yloxy)-3-tosyloxy]propoxy]quinoline

2-(4-dimethylaminophenyl)-6-[[2-(tetrahydro-2H-pyran-2-yloxy)-3-tosyloxy]propoxy]quinoline