5-chloro-N-tert-butyl-N-{[(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]oxazolidin-5-yl]methyl}thiophene-2-carboxamide

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Chemical Name:5-chloro-N-tert-butyl-N-{[(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]oxazolidin-5-yl]methyl}thiophene-2-carboxamide
CAS No.:1313613-21-6
Molecular Formula:C₂₃H₂₆ClN₃O₅S
Molecular Weight:491.996
Hs Code.:

Synonyms:5-chloro-N-tert-butyl-N-{[(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]oxazolidin-5-yl]methyl}thiophene-2-carboxamide

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Chemical Property of 5-chloro-N-tert-butyl-N-{[(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]oxazolidin-5-yl]methyl}thiophene-2-carboxamide

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Technology Process of 5-chloro-N-tert-butyl-N-{[(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]oxazolidin-5-yl]methyl}thiophene-2-carboxamide

There total 10 articles about 5-chloro-N-tert-butyl-N-{[(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]oxazolidin-5-yl]methyl}thiophene-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 42518-98-9
5-chlorothiophene-2-carbonyl chloride

: 1313613-19-2
4-(4-((S)-5-(tert-butylaminomethyl)-2-oxooxazolidin-3-yl)phenyl)morpholin-3-one

: 1313613-21-6
5-chloro-N-tert-butyl-N-{[(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]oxazolidin-5-yl]methyl}thiophene-2-carboxamide

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 24h;

Reference yield:

: 29518-11-4
4-phenylmorpholin-3-one

: 1313613-21-6
5-chloro-N-tert-butyl-N-{[(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]oxazolidin-5-yl]methyl}thiophene-2-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1: nitric acid; sulfuric acid / 1 h / -10 °C

2: hydrogen / 5% Pd(II)/C(eggshell) / water; tetrahydrofuran / 6.5 h / 70 °C / 2250.23 Torr

3: sodium hydrogencarbonate / water; acetone / 4 h / 20 °C

4: lithium tert-butoxide / tetrahydrofuran / 24 h / 20 °C

5: triethylamine / dichloromethane / 4 h / 20 °C

6: isopropyl alcohol / 12 h / 120 °C

7: triethylamine / dichloromethane / 24 h / 20 °C

With sulfuric acid; hydrogen; nitric acid; sodium hydrogencarbonate; triethylamine; lithium tert-butoxide; 5% Pd(II)/C(eggshell); In tetrahydrofuran; dichloromethane; water; isopropyl alcohol; acetone;

Reference yield:

: 122-98-5
2-Anilinoethanol

: 1313613-21-6
5-chloro-N-tert-butyl-N-{[(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]oxazolidin-5-yl]methyl}thiophene-2-carboxamide

Guidance literature:: Multi-step reaction with 8 steps

1: sodium hydroxide / isopropyl alcohol / 0 - 40 °C / pH 7 - 8

2: nitric acid; sulfuric acid / 1 h / -10 °C

3: hydrogen / 5% Pd(II)/C(eggshell) / water; tetrahydrofuran / 6.5 h / 70 °C / 2250.23 Torr

4: sodium hydrogencarbonate / water; acetone / 4 h / 20 °C

5: lithium tert-butoxide / tetrahydrofuran / 24 h / 20 °C

6: triethylamine / dichloromethane / 4 h / 20 °C

7: isopropyl alcohol / 12 h / 120 °C

8: triethylamine / dichloromethane / 24 h / 20 °C

With sulfuric acid; hydrogen; nitric acid; sodium hydrogencarbonate; triethylamine; sodium hydroxide; lithium tert-butoxide; 5% Pd(II)/C(eggshell); In tetrahydrofuran; dichloromethane; water; isopropyl alcohol; acetone;