N-cyclopropyl-4-(5-(((1S,2R)-2-hydroxycyclohexyl)amino)-7-((((R)-tetrahydrofuran-3-yl)methyl)amino)pyrazolo[1,5-a]pyrimidin-3-yl)-2-methylbenzamide

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Chemical Name:N-cyclopropyl-4-(5-(((1S,2R)-2-hydroxycyclohexyl)amino)-7-((((R)-tetrahydrofuran-3-yl)methyl)amino)pyrazolo[1,5-a]pyrimidin-3-yl)-2-methylbenzamide
CAS No.:1610677-29-6
Molecular Formula:C₂₈H₃₆N₆O₃
Molecular Weight:504.632
Hs Code.:

Synonyms:N-cyclopropyl-4-(5-(((1S,2R)-2-hydroxycyclohexyl)amino)-7-((((R)-tetrahydrofuran-3-yl)methyl)amino)pyrazolo[1,5-a]pyrimidin-3-yl)-2-methylbenzamide

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Chemical Property of N-cyclopropyl-4-(5-(((1S,2R)-2-hydroxycyclohexyl)amino)-7-((((R)-tetrahydrofuran-3-yl)methyl)amino)pyrazolo[1,5-a]pyrimidin-3-yl)-2-methylbenzamide

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Technology Process of N-cyclopropyl-4-(5-(((1S,2R)-2-hydroxycyclohexyl)amino)-7-((((R)-tetrahydrofuran-3-yl)methyl)amino)pyrazolo[1,5-a]pyrimidin-3-yl)-2-methylbenzamide

There total 2 articles about N-cyclopropyl-4-(5-(((1S,2R)-2-hydroxycyclohexyl)amino)-7-((((R)-tetrahydrofuran-3-yl)methyl)amino)pyrazolo[1,5-a]pyrimidin-3-yl)-2-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₃H₄₄N₆O₅

: 1610677-29-6
N-cyclopropyl-4-(5-(((1S,2R)-2-hydroxycyclohexyl)amino)-7-((((R)-tetrahydrofuran-3-yl)methyl)amino)pyrazolo[1,5-a]pyrimidin-3-yl)-2-methylbenzamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane;

Reference yield:

: 1351374-48-5
N-cyclopropyl-2-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide

: 1610679-91-8
tert-butyl (3-bromo-5-(((1S,2R)-2-hydroxycyclohexyl)amino)pyrazolo[1,5-a]pyrimidin-7-yl)(((R)-tetrahydrofuran-3-yl)methyl)carbamate

: 1610677-29-6
N-cyclopropyl-4-(5-(((1S,2R)-2-hydroxycyclohexyl)amino)-7-((((R)-tetrahydrofuran-3-yl)methyl)amino)pyrazolo[1,5-a]pyrimidin-3-yl)-2-methylbenzamide

Guidance literature:: Multi-step reaction with 2 steps

1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium phosphate / tetrahydrofuran / 80 - 130 °C / Inert atmosphere; Microwave irradiation

2: trifluoroacetic acid / dichloromethane

With potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;