(3-{4-[(2S,3R)-3-[(3S)-3-(acetyloxy)-3-(4-fluorophenyl)propyl]-1-(4-{[2-(aminocarbonyI)-1,3-thiazol-4-yl]ethyl}phenyl)-4-oxoazetidin-2-yl]phenyl}propyl)malonic acid

Base Information

• Chemical Name: (3-{4-[(2S,3R)-3-[(3S)-3-(acetyloxy)-3-(4-fluorophenyl)propyl]-1-(4-{[2-(aminocarbonyI)-1,3-thiazol-4-yl]ethyl}phenyl)-4-oxoazetidin-2-yl]phenyl}propyl)malonic acid
• CAS No.: 1227267-96-0
• Molecular Formula: C₃₈H₃₈FN₃O₈S
• Molecular Weight: 715.799

Synonyms:(3-{4-[(2S,3R)-3-[(3S)-3-(acetyloxy)-3-(4-fluorophenyl)propyl]-1-(4-{[2-(aminocarbonyI)-1,3-thiazol-4-yl]ethyl}phenyl)-4-oxoazetidin-2-yl]phenyl}propyl)malonic acid

Chemical Property of (3-{4-[(2S,3R)-3-[(3S)-3-(acetyloxy)-3-(4-fluorophenyl)propyl]-1-(4-{[2-(aminocarbonyI)-1,3-thiazol-4-yl]ethyl}phenyl)-4-oxoazetidin-2-yl]phenyl}propyl)malonic acid

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Technology Process of (3-{4-[(2S,3R)-3-[(3S)-3-(acetyloxy)-3-(4-fluorophenyl)propyl]-1-(4-{[2-(aminocarbonyI)-1,3-thiazol-4-yl]ethyl}phenyl)-4-oxoazetidin-2-yl]phenyl}propyl)malonic acid

There total 1 articles about (3-{4-[(2S,3R)-3-[(3S)-3-(acetyloxy)-3-(4-fluorophenyl)propyl]-1-(4-{[2-(aminocarbonyI)-1,3-thiazol-4-yl]ethyl}phenyl)-4-oxoazetidin-2-yl]phenyl}propyl)malonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

dibenzyl (3-{4-[(2S,3R)-3-[(3S)-3-(acetyloxy)-3-(4-fluorophenyl)propyl]-1-(4-{[2-(aminocarbonyI)-1,3-thiazol-4-yl]ethynyl}phenyl)-4-oxoazetidin-2-yl]phenyl}prop-2-yn-1-yl)malonate (1227267-95-9) → (3-{4-[(2S,3R)-3-[(3S)-3-(acetyloxy)-3-(4-fluorophenyl)propyl]-1-(4-{[2-(aminocarbonyI)-1,3-thiazol-4-yl]ethyl}phenyl)-4-oxoazetidin-2-yl]phenyl}propyl)malonic acid (1227267-96-0)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In ethanol; at 20 ℃; for 2h; under 760.051 Torr;

Reference yield:

(3-{4-[(2S,3R)-3-[(3S)-3-(acetyloxy)-3-(4-fluorophenyl)propyl]-1-(4-{[2-(aminocarbonyI)-1,3-thiazol-4-yl]ethyl}phenyl)-4-oxoazetidin-2-yl]phenyl}propyl)malonic acid (1227267-96-0) → [3-(4-{(2S,3R)-1-(4-{2-[2-(aminocarbonyl)-1,3-thiazol-4-yl]ethyl}phenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-oxoazetidin-2 yl}phenyl)propyl]malonic acid (1227267-62-0)

Guidance literature:

With potassium trimethylsilonate; In ethanol; at 20 ℃; for 2h;

upstream raw materials:

dibenzyl (3-{4-[(2S,3R)-3-[(3S)-3-(acetyloxy)-3-(4-fluorophenyl)propyl]-1-(4-{[2-(aminocarbonyI)-1,3-thiazol-4-yl]ethynyl}phenyl)-4-oxoazetidin-2-yl]phenyl}prop-2-yn-1-yl)malonate

Downstream raw materials:

[3-(4-{(2S,3R)-1-(4-{2-[2-(aminocarbonyl)-1,3-thiazol-4-yl]ethyl}phenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-oxoazetidin-2 yl}phenyl)propyl]malonic acid

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