tert-butyl (1-(5-oxo-4-(m-tolylamino)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-yl)piperidin-2-yl)methylcarbamate

Base Information

Chemical Name:tert-butyl (1-(5-oxo-4-(m-tolylamino)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-yl)piperidin-2-yl)methylcarbamate
CAS No.:1312691-48-7
Molecular Formula:C₂₄H₃₂N₆O₃
Molecular Weight:452.556
Hs Code.:

Synonyms:tert-butyl (1-(5-oxo-4-(m-tolylamino)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-yl)piperidin-2-yl)methylcarbamate

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Chemical Property of tert-butyl (1-(5-oxo-4-(m-tolylamino)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-yl)piperidin-2-yl)methylcarbamate

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Technology Process of tert-butyl (1-(5-oxo-4-(m-tolylamino)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-yl)piperidin-2-yl)methylcarbamate

There total 5 articles about tert-butyl (1-(5-oxo-4-(m-tolylamino)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-yl)piperidin-2-yl)methylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1312691-47-6
methyl 2-(2-((tert-butoxycarbonylamino)methyl)piperidin-1-yl)-4-cyano-6-(m-tolylamino)pyrimidine-5-carboxylate

: 1312691-48-7
tert-butyl (1-(5-oxo-4-(m-tolylamino)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-yl)piperidin-2-yl)methylcarbamate

Guidance literature:: methyl 2-(2-((tert-butoxycarbonylamino)methyl)piperidin-1-yl)-4-cyano-6-(m-tolylamino)pyrimidine-5-carboxylate; With hydrogenchloride; hydrogen; palladium on carbon; In ethanol; water; at 20 ℃; for 16h; under 760.051 Torr;

With sodium hydrogencarbonate; In ethanol; water;

Reference yield:

: 1312690-70-2
methyl 2,4-dichloro-6-(m-tolylamino)pyrimidine-5-carboxylate

: 1312691-48-7
tert-butyl (1-(5-oxo-4-(m-tolylamino)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-yl)piperidin-2-yl)methylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 3 h / 0 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 1 h / 120 °C / Microwave irradiation

3: hydrogenchloride; hydrogen / palladium on carbon / ethanol; water / 16 h / 20 °C / 760.05 Torr

With hydrogenchloride; hydrogen; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium on carbon; In ethanol; water; N,N-dimethyl-formamide;

Reference yield:

: 1312690-71-3
2,4-dichloro-6-(m-tolylamino)pyrimidine-5-carboxylic acid

: 1312691-48-7
tert-butyl (1-(5-oxo-4-(m-tolylamino)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-yl)piperidin-2-yl)methylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydrogencarbonate / N,N-dimethyl-formamide / 14 h / 0 - 20 °C

2: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 3 h / 0 °C

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 1 h / 120 °C / Microwave irradiation

4: hydrogenchloride; hydrogen / palladium on carbon / ethanol; water / 16 h / 20 °C / 760.05 Torr

With hydrogenchloride; hydrogen; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium on carbon; In ethanol; water; N,N-dimethyl-formamide;