2-[(1-benzyloxycarbonylamino-2-phenyl-ethyl)-hydroxy-phosphinoylmethyl]-5-phenyl-pentanoic acid ethyl ester

Base Information

Chemical Name:2-[(1-benzyloxycarbonylamino-2-phenyl-ethyl)-hydroxy-phosphinoylmethyl]-5-phenyl-pentanoic acid ethyl ester
CAS No.:237394-24-0
Molecular Formula:C₃₀H₃₆NO₆P
Molecular Weight:537.593
Hs Code.:

Synonyms:2-[(1-benzyloxycarbonylamino-2-phenyl-ethyl)-hydroxy-phosphinoylmethyl]-5-phenyl-pentanoic acid ethyl ester

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Chemical Property of 2-[(1-benzyloxycarbonylamino-2-phenyl-ethyl)-hydroxy-phosphinoylmethyl]-5-phenyl-pentanoic acid ethyl ester

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Technology Process of 2-[(1-benzyloxycarbonylamino-2-phenyl-ethyl)-hydroxy-phosphinoylmethyl]-5-phenyl-pentanoic acid ethyl ester

There total 1 articles about 2-[(1-benzyloxycarbonylamino-2-phenyl-ethyl)-hydroxy-phosphinoylmethyl]-5-phenyl-pentanoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 27356-88-3
ethyl 2-methylene-5-phenylpentanoate

: 115961-49-4
[2-phenyl-1-[[(phenylmethoxy)carbonyl]amino]ethyl]phosphinic acid

: 237394-24-0
2-[(1-benzyloxycarbonylamino-2-phenyl-ethyl)-hydroxy-phosphinoylmethyl]-5-phenyl-pentanoic acid ethyl ester

Guidance literature:: With 1,1,1,3,3,3-hexamethyl-disilazane; Yield given; Multistep reaction; 1.) 110 deg C, 1 h, 2.) 110 deg C, 3 h;
DOI:10.1021/jm9900164

Reference yield: 75.0%

: 768-90-1
1-Adamantyl bromide

: 237394-24-0
2-[(1-benzyloxycarbonylamino-2-phenyl-ethyl)-hydroxy-phosphinoylmethyl]-5-phenyl-pentanoic acid ethyl ester

: 237394-38-6
2-[(adamantan-1-yloxy)-(1-benzyloxycarbonylamino-2-phenyl-ethyl)-phosphinoylmethyl]-5-phenyl-pentanoic acid ethyl ester

Guidance literature:: With silver(l) oxide; In chloroform; for 0.5h; Heating;
DOI:10.1021/jm9900164

Reference yield:

: 237394-24-0
2-[(1-benzyloxycarbonylamino-2-phenyl-ethyl)-hydroxy-phosphinoylmethyl]-5-phenyl-pentanoic acid ethyl ester

: 237394-58-0
2-{(adamantan-1-yloxy)-[1-(9H-fluoren-9-ylmethoxycarbonylamino)-2-phenyl-ethyl]-phosphinoylmethyl}-5-phenyl-pentanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 75 percent / silver oxide / CHCl₃ / 0.5 h / Heating

2: 97 percent / 4N aq. NaOH / methanol / 18 h

3: ammonium formate / 10 percent Pd/C / methanol / 0.2 h / Ambient temperature

4: aq. Na₂CO₃ / dioxane / 1.) 4 deg C, 2 h, 2.) RT, 4 h

With sodium hydroxide; ammonium formate; sodium carbonate; silver(l) oxide; palladium on activated charcoal; In 1,4-dioxane; methanol; chloroform;
DOI:10.1021/jm9900164