(S)-tert-butyl 2-cyano-2-(2,2,2-trifluoro-1-(2-nitrophenylamino)ethyl)pentanoate

Base Information

• Chemical Name: (S)-tert-butyl 2-cyano-2-(2,2,2-trifluoro-1-(2-nitrophenylamino)ethyl)pentanoate
• CAS No.: 1004973-45-8
• Molecular Formula: C₁₈H₂₂F₃N₃O₄
• Molecular Weight: 401.386

Synonyms:(S)-tert-butyl 2-cyano-2-(2,2,2-trifluoro-1-(2-nitrophenylamino)ethyl)pentanoate

Chemical Property of (S)-tert-butyl 2-cyano-2-(2,2,2-trifluoro-1-(2-nitrophenylamino)ethyl)pentanoate

Chemical Property:

Purity/Quality:

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Technology Process of (S)-tert-butyl 2-cyano-2-(2,2,2-trifluoro-1-(2-nitrophenylamino)ethyl)pentanoate

There total 1 articles about (S)-tert-butyl 2-cyano-2-(2,2,2-trifluoro-1-(2-nitrophenylamino)ethyl)pentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-cyanopentanoic acid tert-butyl ester (927895-19-0) + (Z)-2,2,2-trifluoro-N-(2-nitrophenyl)acetimidoyl chloride (1004972-86-4) → (S)-tert-butyl 2-cyano-2-(2,2,2-trifluoro-1-(2-nitrophenylamino)ethyl)pentanoate (1004973-45-8)

Guidance literature:

2-cyanopentanoic acid tert-butyl ester; (Z)-2,2,2-trifluoro-N-(2-nitrophenyl)acetimidoyl chloride; With potassium hydroxide; In chloroform; o-xylene; at -20 ℃; for 18h;

With sodium tetrahydroborate; lithium perchlorate; In ethanol; at -78 - 20 ℃; Further stages.;

DOI:10.1039/b715810f

Reference yield: 99.0%

(S)-tert-butyl 2-cyano-2-(2,2,2-trifluoro-1-(2-nitrophenylamino)ethyl)pentanoate (1004973-45-8) → (S)-tert-butyl 2-(1-(2-aminophenylamino)-2,2,2-trifluoroethyl)-2-cyanopentanoate (1004973-47-0)

Guidance literature:

With hydrogen; palladium hydroxide - carbon; In ethanol; for 20h;

DOI:10.1039/b715810f

upstream raw materials:

2-cyanopentanoic acid tert-butyl ester

(Z)-2,2,2-trifluoro-N-(2-nitrophenyl)acetimidoyl chloride

Downstream raw materials:

(S)-tert-butyl 2-(1-(2-aminophenylamino)-2,2,2-trifluoroethyl)-2-cyanopentanoate

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