Technology Process of ST5610
There total 17 articles about ST5610 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
cyclopropanecarboxylic acid (E)-3-adamantan-1-yl-4'-(2-tert-butyldiphenylsilyloxycarbonylvinyl)biphenyl-4-yl ester;
With
tetrabutyl ammonium fluoride;
In
tetrahydrofuran;
at -78 ℃;
for 0.5h;
With
ammonium chloride;
In
tetrahydrofuran;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: palladium diacetate; triethylamine; tris-(o-tolyl)phosphine / 1 h / 110 °C / Neat (no solvent)
2.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide
2.2: 5 h / 0 °C
3.1: dichloromethane / 20 °C
4.1: water / dimethyl sulfoxide / 24 h / 37 °C / pH 7.4 / aq. buffer
5.1: morpholine / N,N-dimethyl-formamide / 0.33 h / 20 °C / Inert atmosphere
6.1: pyridine / 0.5 h / 50 °C
7.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere
With
morpholine; pyridine; tetrabutyl ammonium fluoride; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; water; palladium diacetate; triethylamine; N-ethyl-N,N-diisopropylamine; tris-(o-tolyl)phosphine;
In
tetrahydrofuran; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
1.1: Heck reaction;
DOI:10.1016/j.bmc.2012.01.042
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide
1.2: 5 h / 0 °C
2.1: dichloromethane / 20 °C
3.1: water / dimethyl sulfoxide / 24 h / 37 °C / pH 7.4 / aq. buffer
4.1: morpholine / N,N-dimethyl-formamide / 0.33 h / 20 °C / Inert atmosphere
5.1: pyridine / 0.5 h / 50 °C
6.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere
With
morpholine; pyridine; tetrabutyl ammonium fluoride; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; water; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2012.01.042
