PF-03715455

Base Information

Chemical Name:PF-03715455
CAS No.:1056164-52-3
Molecular Formula:C₃₅H₃₄ClN₇O₃S₂
Molecular Weight:700.285
Hs Code.:
UNII:0TJ631J0KP
ChEMBL ID:CHEMBL1938400
DSSTox Substance ID:DTXSID70147214
Metabolomics Workbench ID:153182
Pharos Ligand ID:NRPY9K4LX7NJ
Wikidata:Q27088311

Synonyms:N-(1-(3-chloro-4-hydroxyphenyl)-3-(1,1-dimethylethyl)-1H-pyrazol-5-yl)-N'-((2-((3-(2-((2-hydroxyethyl)thio)phenyl)-1,2,4-triazolo(4,3-a)pyridin-6-yl)thio)phenyl)methyl)-urea;PF 03715455;PF-03715455;PF-3715455;PF03715455

Suppliers and Price of PF-03715455

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

DC Chemicals
PF03715455 >98%
5mg
$ 850.00

Total 2 raw suppliers

Chemical Property of PF-03715455

Chemical Property:

Melting Point:220 °C
Density:1.39±0.1 g/cm3(Predicted)
XLogP3:7.5
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:11
Exact Mass:699.1853080
Heavy Atom Count:48
Complexity:1040

Purity/Quality:

95% ^*data from raw suppliers

PF03715455 >98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C)(C)C1=NN(C(=C1)NC(=O)NCC2=CC=CC=C2SC3=CN4C(=NN=C4C5=CC=CC=C5SCCO)C=C3)C6=CC(=C(C=C6)O)Cl
Recent ClinicalTrials:An Evaluation Of PF-03715455 In Moderate To Severe Uncontrolled Asthma
Recent EU Clinical Trials:A Randomized, Double-Blind, Placebo-Controlled 2-Way Crossover Study to Evaluate the Efficacy, Safety and Tolerability of PF-03715455 Administered Twice Daily By Inhalation for 4 Weeks in Subjects with Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD)

Technology Process of PF-03715455

There total 10 articles about PF-03715455 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1344738-31-3
1-[3-tert-butyl-1-(3-chloro-4-hydroxyphenyl)-1H-pyrazol-5-yl]-3-{2-[(3-{2-[(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)thio]phenyl}[1,2,4]triazolo[4,3-a]pyridin-6-yl)thio]benzyl}urea

: 1056164-52-3
(1-[5-tert-butyl-2-(3-chloro-4-hydroxyphenyl)pyrazol-3-yl]-3-[[2-[[3-[2-(2-hydroxyethylsulfanyl)phenyl]-[1,2,4]triazolo[4,3-a]pyridin-6-yl]sulfanyl]phenyl]methyl]urea)

Guidance literature:: With triethylamine tris(hydrogen fluoride); In methanol; at 20 ℃; Inert atmosphere;
DOI:10.1021/jm200677b

Reference yield:

: 1344738-18-6
1-{2-[(3-{2-[(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)thio]-phenyl}[1,2,4]triazolo[4,3-a]pyridin-6-yl)thio]phenyl}methanamine

: 1056164-52-3
(1-[5-tert-butyl-2-(3-chloro-4-hydroxyphenyl)pyrazol-3-yl]-3-[[2-[[3-[2-(2-hydroxyethylsulfanyl)phenyl]-[1,2,4]triazolo[4,3-a]pyridin-6-yl]sulfanyl]phenyl]methyl]urea)

Guidance literature:: Multi-step reaction with 2 steps

1: dimethyl sulfoxide / 20 °C / Inert atmosphere

2: triethylamine tris(hydrogen fluoride) / methanol / 20 °C / Inert atmosphere

With triethylamine tris(hydrogen fluoride); In methanol; dimethyl sulfoxide;
DOI:10.1021/jm200677b

Reference yield:

: 945995-00-6
phenyl [3-tert-butyl-1-(4-{[tert-butyl(dimethyl)silyl]oxy}-3-chlorophenyl)-1H-pyrazol-5-yl]carbamate

: 1056164-52-3
(1-[5-tert-butyl-2-(3-chloro-4-hydroxyphenyl)pyrazol-3-yl]-3-[[2-[[3-[2-(2-hydroxyethylsulfanyl)phenyl]-[1,2,4]triazolo[4,3-a]pyridin-6-yl]sulfanyl]phenyl]methyl]urea)

Guidance literature:: Multi-step reaction with 2 steps

1: dimethyl sulfoxide / 20 °C / Inert atmosphere

2: triethylamine tris(hydrogen fluoride) / methanol / 20 °C / Inert atmosphere

With triethylamine tris(hydrogen fluoride); In methanol; dimethyl sulfoxide;
DOI:10.1021/jm200677b