4-methoxy-3-(pyrrolidine-1-carbonyl)-5-trifluoromethylbenzoyl chloride

Base Information

Chemical Name:4-methoxy-3-(pyrrolidine-1-carbonyl)-5-trifluoromethylbenzoyl chloride
CAS No.:1285575-81-6
Molecular Formula:C₁₄H₁₃ClF₃NO₃
Molecular Weight:335.71
Hs Code.:

Synonyms:4-methoxy-3-(pyrrolidine-1-carbonyl)-5-trifluoromethylbenzoyl chloride

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Chemical Property of 4-methoxy-3-(pyrrolidine-1-carbonyl)-5-trifluoromethylbenzoyl chloride

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Technology Process of 4-methoxy-3-(pyrrolidine-1-carbonyl)-5-trifluoromethylbenzoyl chloride

There total 12 articles about 4-methoxy-3-(pyrrolidine-1-carbonyl)-5-trifluoromethylbenzoyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1285575-79-2
4-methoxy-3-(pyrrolidine-1-carbonyl)-5-trifluoromethylbenzoic acid

: 1285575-81-6
4-methoxy-3-(pyrrolidine-1-carbonyl)-5-trifluoromethylbenzoyl chloride

Guidance literature:: With oxalyl dichloride; N,N-dimethyl-formamide; In toluene; at 20 ℃; for 22h;

Reference yield:

: 1285575-77-0
methyl 4-methoxy-3-(pyrrolidine-1-carbonyl)-5-trifluoromethyl benzoate

: 1285575-81-6
4-methoxy-3-(pyrrolidine-1-carbonyl)-5-trifluoromethylbenzoyl chloride

Guidance literature:: Multi-step reaction with 2 steps

1: lithium hydroxide monohydrate; water / tetrahydrofuran / 1 h / 20 °C

2: oxalyl dichloride / N,N-dimethyl-formamide / toluene / 22 h / 20 °C

With oxalyl dichloride; lithium hydroxide monohydrate; water; N,N-dimethyl-formamide; In tetrahydrofuran; toluene;

Reference yield:

: 444-30-4
2-(trifluoromethyl)phenol

: 1285575-81-6
4-methoxy-3-(pyrrolidine-1-carbonyl)-5-trifluoromethylbenzoyl chloride

Guidance literature:: Multi-step reaction with 12 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 1 h

2.1: n-butyllithium / tetrahydrofuran; hexane / 1.75 h / -70 °C / Inert atmosphere

2.2: 0.5 h / 20 °C

3.1: hydrogenchloride; water / tetrahydrofuran; hexane / 16 h / 60 °C

4.1: N-Bromosuccinimide / acetonitrile / 1 h / 0 °C

5.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C

6.1: Amberlyst-15 / hexane / 3 h / Reflux

7.1: magnesium / tetrahydrofuran / 1.5 h / 20 °C

7.2: 1 h / 0 °C

7.3: 16 h / 20 °C

8.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / 1.5 h / 20 °C

9.1: sodium chlorite; 2-methyl-but-2-ene; citric acid / water; acetonitrile / 1 h / 20 °C

10.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 16 h / 20 °C

11.1: lithium hydroxide monohydrate; water / tetrahydrofuran / 1 h / 20 °C

12.1: oxalyl dichloride / N,N-dimethyl-formamide / toluene / 22 h / 20 °C

With hydrogenchloride; sodium chlorite; N-Bromosuccinimide; n-butyllithium; 2-methyl-but-2-ene; oxalyl dichloride; lithium hydroxide monohydrate; water; potassium carbonate; magnesium; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; citric acid; N,N-dimethyl-formamide; In tetrahydrofuran; hexane; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile;