ethyl m-hydrazinecarbonyl benzoate

Base Information

• Chemical Name: ethyl m-hydrazinecarbonyl benzoate
• CAS No.: 110925-44-5
• Molecular Formula: C₁₀H₁₂N₂O₃
• Molecular Weight: 208.217
• Mol file: 110925-44-5.mol

Synonyms:ethyl m-hydrazinecarbonyl benzoate

Chemical Property of ethyl m-hydrazinecarbonyl benzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl m-hydrazinecarbonyl benzoate

There total 2 articles about ethyl m-hydrazinecarbonyl benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-[1-[(2S,4S)-4-((2R,4S,5S,6S)-4-Amino-5-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydro-naphthacen-2-yl]-eth-(E)-ylidene-hydrazinocarbonyl]-benzoic acid ethyl ester; hydrochloride (110925-36-5) → daunomycin hydrochloride (23541-50-6) + ethyl m-hydrazinecarbonyl benzoate (110925-44-5)

Guidance literature:

With water; at 37 ℃; Rate constant; also half-conversion period, pH 5.58, 0.01 M phosphate buffer;

DOI:10.1007/BF00758626

Reference yield:

C15H20N2O5 (1247691-89-9) → ethyl m-hydrazinecarbonyl benzoate (110925-44-5)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

DOI:10.1016/j.bmcl.2010.07.040

Reference yield: 70.0%

daunomycin hydrochloride (23541-50-6) + ethyl m-hydrazinecarbonyl benzoate (110925-44-5) → 3-[1-[(2S,4S)-4-((2R,4S,5S,6S)-4-Amino-5-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydro-naphthacen-2-yl]-eth-(E)-ylidene-hydrazinocarbonyl]-benzoic acid ethyl ester; hydrochloride (110925-36-5)

Guidance literature:

In methanol; Heating;

DOI:10.1007/BF00758626

upstream raw materials:

3-[1-[(2S,4S)-4-((2R,4S,5S,6S)-4-Amino-5-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydro-naphthacen-2-yl]-eth-(E)-ylidene-hydrazinocarbonyl]-benzoic acid ethyl ester; hydrochloride

C₁₅H₂₀N₂O₅

Downstream raw materials:

3-[1-[(2S,4S)-4-((2R,4S,5S,6S)-4-Amino-5-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydro-naphthacen-2-yl]-eth-(E)-ylidene-hydrazinocarbonyl]-benzoic acid ethyl ester; hydrochloride

C₂₇H₂₄FN₃O₄

C₂₇H₂₅N₃O₄

C₂₈H₂₇N₃O₄

Refernces

• 1、 Rozin, Yu. A.,Buryndina, E. I.,Batulina, R. Kh.,Bobrova, T. M.,Krupnova, L. V.,Barybin, A. S.. "SYNTHESIS AND PROPERTIES OF HYDRAZONES OF THE ANTITUMOR ANTIBIOTIC RUBOMYCIN". . p. 398 - 402. Retrieved 2007/10/02.