ethyl (2E)-3-{[(4-methylphenyl)sulfonyl](3-phenylprop-2-yn-1-yl)amino}but-2-enoate

Base Information

• Chemical Name: ethyl (2E)-3-{[(4-methylphenyl)sulfonyl](3-phenylprop-2-yn-1-yl)amino}but-2-enoate
• CAS No.: 1204504-81-3
• Molecular Formula: C₂₂H₂₃NO₄S
• Molecular Weight: 397.495
• Mol file: 1204504-81-3.mol

Synonyms:ethyl (2E)-3-{[(4-methylphenyl)sulfonyl](3-phenylprop-2-yn-1-yl)amino}but-2-enoate

Chemical Property of ethyl (2E)-3-{[(4-methylphenyl)sulfonyl](3-phenylprop-2-yn-1-yl)amino}but-2-enoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of ethyl (2E)-3-{[(4-methylphenyl)sulfonyl](3-phenylprop-2-yn-1-yl)amino}but-2-enoate

There total 1 articles about ethyl (2E)-3-{[(4-methylphenyl)sulfonyl](3-phenylprop-2-yn-1-yl)amino}but-2-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Ethyl 2-butynoate (4341-76-8) + 4-methyl-N-(3-phenylprop-2-yn-1-yl)benzenesulfonamide (305837-95-0) → ethyl (2E)-3-{[(4-methylphenyl)sulfonyl](3-phenylprop-2-yn-1-yl)amino}but-2-enoate (1204504-81-3)

Guidance literature:

With 1,4-diaza-bicyclo[2.2.2]octane; In benzene; Inert atmosphere; Reflux;

DOI:10.1021/ol902716n

Reference yield: 85.0%

ethyl (2E)-3-{[(4-methylphenyl)sulfonyl](3-phenylprop-2-yn-1-yl)amino}but-2-enoate (1204504-81-3) → ethyl 2,5-dimethyl-4-phenyl-1-tosyl-1H-pyrrole-3-carboxylate (1204504-87-9)

Guidance literature:

With 1,3-bis(2,6-di-i-propylphenyl)imidazol-2-ylidene(acetonitrile)gold(I) tetrafluoroborate; In hexafluoropropan-2-ol; at 20 ℃; for 2h; Inert atmosphere;

DOI:10.1021/ol902716n

upstream raw materials:

Ethyl 2-butynoate

4-methyl-N-(3-phenylprop-2-yn-1-yl)benzenesulfonamide

Downstream raw materials:

ethyl 2,5-dimethyl-4-phenyl-1-tosyl-1H-pyrrole-3-carboxylate