methyl 4-{3'-[2-(benzyloxy)ethyl]-5'-methoxy-6,6-dimethyl-2,4-dioxospiro[1,5-dioxane-3,1'-indene]-2'-yl}benzoate

Base Information

Chemical Name:methyl 4-{3'-[2-(benzyloxy)ethyl]-5'-methoxy-6,6-dimethyl-2,4-dioxospiro[1,5-dioxane-3,1'-indene]-2'-yl}benzoate
CAS No.:1439383-37-5
Molecular Formula:C₃₂H₃₀O₈
Molecular Weight:542.585
Hs Code.:

Synonyms:methyl 4-{3'-[2-(benzyloxy)ethyl]-5'-methoxy-6,6-dimethyl-2,4-dioxospiro[1,5-dioxane-3,1'-indene]-2'-yl}benzoate

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Chemical Property of methyl 4-{3'-[2-(benzyloxy)ethyl]-5'-methoxy-6,6-dimethyl-2,4-dioxospiro[1,5-dioxane-3,1'-indene]-2'-yl}benzoate

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Technology Process of methyl 4-{3'-[2-(benzyloxy)ethyl]-5'-methoxy-6,6-dimethyl-2,4-dioxospiro[1,5-dioxane-3,1'-indene]-2'-yl}benzoate

There total 5 articles about methyl 4-{3'-[2-(benzyloxy)ethyl]-5'-methoxy-6,6-dimethyl-2,4-dioxospiro[1,5-dioxane-3,1'-indene]-2'-yl}benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 1439383-43-3
5-(4-methoxyphenyl)-2,2-dimethyl-1,3-dioxane-4,6-dione

: 1439383-46-6
methyl 4-[4-(benzyloxy)but-1-yn-1-yl]benzoate

: 1439383-37-5
methyl 4-{3'-[2-(benzyloxy)ethyl]-5'-methoxy-6,6-dimethyl-2,4-dioxospiro[1,5-dioxane-3,1'-indene]-2'-yl}benzoate

Guidance literature:: With [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂; copper diacetate; potassium carbonate; In 1,4-dioxane; at 90 ℃; for 4h; Inert atmosphere;
DOI:10.1002/anie.201207170

Reference yield:

: 619-44-3
methyl 4-iodobenzoate

: 1439383-37-5
methyl 4-{3'-[2-(benzyloxy)ethyl]-5'-methoxy-6,6-dimethyl-2,4-dioxospiro[1,5-dioxane-3,1'-indene]-2'-yl}benzoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 0.08 h / 20 °C / Inert atmosphere

1.2: 20 °C / Inert atmosphere

2.1: potassium carbonate; copper diacetate; [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂ / 1,4-dioxane / 4 h / 90 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂; copper diacetate; potassium carbonate; triethylamine; In tetrahydrofuran; 1,4-dioxane;
DOI:10.1002/anie.201207170

Reference yield:

: 53181-45-6
2-(4-methoxyphenyl)propanedioic acid

: 1439383-37-5
methyl 4-{3'-[2-(benzyloxy)ethyl]-5'-methoxy-6,6-dimethyl-2,4-dioxospiro[1,5-dioxane-3,1'-indene]-2'-yl}benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: acetic anhydride; sulfuric acid / 0.17 h / 20 °C / Inert atmosphere

2: potassium carbonate; copper diacetate; [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂ / 1,4-dioxane / 4 h / 90 °C / Inert atmosphere

With [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂; sulfuric acid; copper diacetate; acetic anhydride; potassium carbonate; In 1,4-dioxane;
DOI:10.1002/anie.201207170