1-(3-isopropyl-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(4-((2-((3-methoxy-5-((2-(2-(2-methoxyethoxy)ethoxy)ethyl)sulfonyl)phenyl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)urea

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Chemical Name:1-(3-isopropyl-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(4-((2-((3-methoxy-5-((2-(2-(2-methoxyethoxy)ethoxy)ethyl)sulfonyl)phenyl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)urea
CAS No.:1610449-58-5
Molecular Formula:C₄₂H₄₇N₇O₈S
Molecular Weight:809.943
Hs Code.:

1-(3-isopropyl-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(4-((2-((3-methoxy-5-((2-(2-(2-methoxyethoxy)ethoxy)ethyl)sulfonyl)phenyl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)urea

Synonyms:1-(3-isopropyl-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(4-((2-((3-methoxy-5-((2-(2-(2-methoxyethoxy)ethoxy)ethyl)sulfonyl)phenyl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)urea

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Chemical Property of 1-(3-isopropyl-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(4-((2-((3-methoxy-5-((2-(2-(2-methoxyethoxy)ethoxy)ethyl)sulfonyl)phenyl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)urea

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Technology Process of 1-(3-isopropyl-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(4-((2-((3-methoxy-5-((2-(2-(2-methoxyethoxy)ethoxy)ethyl)sulfonyl)phenyl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)urea

There total 9 articles about 1-(3-isopropyl-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(4-((2-((3-methoxy-5-((2-(2-(2-methoxyethoxy)ethoxy)ethyl)sulfonyl)phenyl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1562518-34-6
1-(4-((2-chloropyrimidin-4-yl)oxy)naphthalen-1-yl)-3-(3-isopropyl-1-(p-tolyl)-1H-pyrazol-5-yl)urea

: 1610450-41-3
3-methoxy-5-((2-(2-(2-methoxyethoxy)ethoxy)ethyl)sulfonyl)aniline

: 1610449-58-5
1-(3-isopropyl-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(4-((2-((3-methoxy-5-((2-(2-(2-methoxyethoxy)ethoxy)ethyl)sulfonyl)phenyl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)urea

Guidance literature:: With toluene-4-sulfonic acid; In tetrahydrofuran; N,N-dimethyl-formamide; at 70 ℃; for 20h;

Reference yield:

: 1536312-09-0
2-((3-methoxy-5-nitrophenyl)thio)ethanol

: 1610449-58-5
1-(3-isopropyl-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(4-((2-((3-methoxy-5-((2-(2-(2-methoxyethoxy)ethoxy)ethyl)sulfonyl)phenyl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)urea

Guidance literature:: Multi-step reaction with 4 steps

1: sodium iodide; sodium hydride / N,N-dimethyl-formamide; mineral oil / 3.5 h / 20 °C / Inert atmosphere

2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 0 - 20 °C

3: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; ethanol / 4 h

4: toluene-4-sulfonic acid / tetrahydrofuran; N,N-dimethyl-formamide / 20 h / 70 °C

With palladium 10% on activated carbon; hydrogen; sodium hydride; toluene-4-sulfonic acid; 3-chloro-benzenecarboperoxoic acid; sodium iodide; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1610450-27-5
(3-methoxy-5-nitrophenyl)(2-(2-(2-methoxyethoxy)ethoxy)ethyl)sulfane

: 1610449-58-5
1-(3-isopropyl-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(4-((2-((3-methoxy-5-((2-(2-(2-methoxyethoxy)ethoxy)ethyl)sulfonyl)phenyl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)urea

Guidance literature:: Multi-step reaction with 3 steps

1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 0 - 20 °C

2: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; ethanol / 4 h

3: toluene-4-sulfonic acid / tetrahydrofuran; N,N-dimethyl-formamide / 20 h / 70 °C

With palladium 10% on activated carbon; hydrogen; toluene-4-sulfonic acid; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;