5-Amino-8-chloro-1-(2-chloro-phenyl)-1H-benzo[c]azepine-4-carbaldehyde oxime

Base Information

• Chemical Name: 5-Amino-8-chloro-1-(2-chloro-phenyl)-1H-benzo[c]azepine-4-carbaldehyde oxime
• CAS No.: 86709-95-7
• Molecular Formula: C₁₇H₁₃Cl₂N₃O
• Molecular Weight: 346.216
• Mol file: 86709-95-7.mol

Synonyms:5-Amino-8-chloro-1-(2-chloro-phenyl)-1H-benzo[c]azepine-4-carbaldehyde oxime

Chemical Property of 5-Amino-8-chloro-1-(2-chloro-phenyl)-1H-benzo[c]azepine-4-carbaldehyde oxime

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-Amino-8-chloro-1-(2-chloro-phenyl)-1H-benzo[c]azepine-4-carbaldehyde oxime

There total 6 articles about 5-Amino-8-chloro-1-(2-chloro-phenyl)-1H-benzo[c]azepine-4-carbaldehyde oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

9-chloro-7-(2-chlorophenyl)-7H-pyrimido<5,4-d><2>benzazepine 3-oxide (86709-94-6) → 9-chloro-7-(2-chlorophenyl)-5H-pyrimido<5,4-d><2>benzazepine 3-oxide (76988-77-7) + 5-Amino-8-chloro-1-(2-chloro-phenyl)-1H-benzo[c]azepine-4-carbaldehyde oxime (86709-95-7)

Guidance literature:

With sodium methylate; In tetrahydrofuran; methanol; for 24h; Ambient temperature;

DOI:10.1021/jm00365a009

Reference yield:

9-chloro-7-(2-chlorophenyl)-5H-pyrimido<5,4-d><2>benzazepine (76988-39-1) → 5-Amino-8-chloro-1-(2-chloro-phenyl)-1H-benzo[c]azepine-4-carbaldehyde oxime (86709-95-7)

Guidance literature:

Multi-step reaction with 6 steps

1: 75 percent / Zn, CH₃COOH / CH₂Cl₂ / 2 h / -30 °C

2: 50 percent / pyridine / CH₂Cl₂ / 1.5 h / 0 °C

3: 21 percent / 85percent m-chloroperbenzoic acid (m-CPBA) / CH₂Cl₂ / 46 h / Ambient temperature

4: 91 percent / 3 N aq. NaOH / ethanol; tetrahydrofuran / 0.5 h / Ambient temperature

5: 1.) Br₂, aq. potassium acetate, 2.) Et₃N / 1.) CH₂Cl₂, RT, 3 h, 2.) CH₂Cl₂, 15 min

6: 25 percent / sodium methoxide / methanol; tetrahydrofuran / 24 h / Ambient temperature

With pyridine; sodium hydroxide; bromine; sodium methylate; potassium acetate; acetic acid; triethylamine; 3-chloro-benzenecarboperoxoic acid; zinc; In tetrahydrofuran; methanol; ethanol; dichloromethane;

DOI:10.1021/jm00365a009

Reference yield:

9-chloro-7-(2-chlorophenyl)-6,7-dihydro-5H-pyrimido<5,4-d><2>benzazepine 3-oxide (76988-79-9) → 5-Amino-8-chloro-1-(2-chloro-phenyl)-1H-benzo[c]azepine-4-carbaldehyde oxime (86709-95-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) Br₂, aq. potassium acetate, 2.) Et₃N / 1.) CH₂Cl₂, RT, 3 h, 2.) CH₂Cl₂, 15 min

2: 25 percent / sodium methoxide / methanol; tetrahydrofuran / 24 h / Ambient temperature

With bromine; sodium methylate; potassium acetate; triethylamine; In tetrahydrofuran; methanol;

DOI:10.1021/jm00365a009

upstream raw materials:

9-chloro-7-(2-chlorophenyl)-7H-pyrimido<5,4-d><2>benzazepine 3-oxide

9-chloro-7-(2-chlorophenyl)-5H-pyrimido<5,4-d><2>benzazepine

9-chloro-7-(2-chlorophenyl)-6,7-dihydro-5H-pyrimido<5,4-d><2>benzazepine 3-oxide

9-chloro-7-(2-chlorophenyl)-6,7-dihydro-6-(trifluoroacetyl)-5H-pyrimido<5,4-d><2>benzazepine