(S)-1,1,1-trifluoro-3-[2-(3-methoxyphenyl)-1,1-dioxo-1λ⁶-thiomorpholin-4-yl]-propan-2-ol

Base Information

• Chemical Name: (S)-1,1,1-trifluoro-3-[2-(3-methoxyphenyl)-1,1-dioxo-1λ⁶-thiomorpholin-4-yl]-propan-2-ol
• CAS No.: 1598382-97-8
• Molecular Formula: C₁₄H₁₈F₃NO₄S
• Molecular Weight: 353.362

Synonyms:(S)-1,1,1-trifluoro-3-[2-(3-methoxyphenyl)-1,1-dioxo-1λ⁶-thiomorpholin-4-yl]-propan-2-ol

Chemical Property of (S)-1,1,1-trifluoro-3-[2-(3-methoxyphenyl)-1,1-dioxo-1λ⁶-thiomorpholin-4-yl]-propan-2-ol

Chemical Property:

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Technology Process of (S)-1,1,1-trifluoro-3-[2-(3-methoxyphenyl)-1,1-dioxo-1λ⁶-thiomorpholin-4-yl]-propan-2-ol

There total 7 articles about (S)-1,1,1-trifluoro-3-[2-(3-methoxyphenyl)-1,1-dioxo-1λ⁶-thiomorpholin-4-yl]-propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(3-methoxyphenyl)thiomorpholine1,1-dioxide (1369007-67-9) + (S)-2-trifluoromethyl-oxirane (130025-34-2) → (S)-1,1,1-trifluoro-3-[2-(3-methoxyphenyl)-1,1-dioxo-1λ6-thiomorpholin-4-yl]-propan-2-ol (1598382-97-8)

Guidance literature:

In dichloromethane; at 20 ℃;

Reference yield:

2-(3-methoxyphenyl)-1,1-dioxo-1λ6-thiomorpholine-4-carboxylic acid tert-butyl ester (1598382-96-7) → (S)-1,1,1-trifluoro-3-[2-(3-methoxyphenyl)-1,1-dioxo-1λ6-thiomorpholin-4-yl]-propan-2-ol (1598382-97-8)

Guidance literature:

Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

2: dichloromethane / 20 °C

With trifluoroacetic acid; In dichloromethane;

Reference yield:

2-(3-methoxyphenyl)-3-thiomorpholinone → (S)-1,1,1-trifluoro-3-[2-(3-methoxyphenyl)-1,1-dioxo-1λ6-thiomorpholin-4-yl]-propan-2-ol (1598382-97-8)

Guidance literature:

Multi-step reaction with 5 steps

1.1: acetic acid; sodium tetrahydroborate / 1,4-dioxane / 0 °C / Reflux

1.2: 20 °C

2.1: acetonitrile / 36 h / 20 °C

3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1.5 h / 20 °C

4.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

5.1: dichloromethane / 20 °C

With sodium tetrahydroborate; acetic acid; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; acetonitrile;

upstream raw materials:

2-(3-methoxyphenyl)thiomorpholine

tert-butyl 2-(3-methoxyphenyl)thiomorpholine-4-carboxylate

2-(3-methoxyphenyl)-1,1-dioxo-1λ⁶-thiomorpholine-4-carboxylic acid tert-butyl ester

2-(3-methoxyphenyl)thiomorpholine1,1-dioxide

Downstream raw materials:

(4-chlorophenyl)-carbamic acid (S)-2,2,2-trifluoro-1-[(R)-2-(3-methoxyphenyl)-1,1-dioxo-1λ⁶-thiomorpholin-4-ylmethyl]-ethyl ester

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