22-Phenylsulfonyl-5α,8α-(4-phenyl-3,5-dioxo-1,2,4-triazolidine-1,2-diyl)-1α,3β-bis(tetrahydropyranyloxy)-23,24-dinor-6-cholene

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Chemical Name:22-Phenylsulfonyl-5α,8α-(4-phenyl-3,5-dioxo-1,2,4-triazolidine-1,2-diyl)-1α,3β-bis(tetrahydropyranyloxy)-23,24-dinor-6-cholene
CAS No.:131249-30-4
Molecular Formula:C₄₆H₅₉N₃O₈S
Molecular Weight:814.056
Hs Code.:

Synonyms:22-Phenylsulfonyl-5α,8α-(4-phenyl-3,5-dioxo-1,2,4-triazolidine-1,2-diyl)-1α,3β-bis(tetrahydropyranyloxy)-23,24-dinor-6-cholene

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Chemical Property of 22-Phenylsulfonyl-5α,8α-(4-phenyl-3,5-dioxo-1,2,4-triazolidine-1,2-diyl)-1α,3β-bis(tetrahydropyranyloxy)-23,24-dinor-6-cholene

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Technology Process of 22-Phenylsulfonyl-5α,8α-(4-phenyl-3,5-dioxo-1,2,4-triazolidine-1,2-diyl)-1α,3β-bis(tetrahydropyranyloxy)-23,24-dinor-6-cholene

There total 6 articles about 22-Phenylsulfonyl-5α,8α-(4-phenyl-3,5-dioxo-1,2,4-triazolidine-1,2-diyl)-1α,3β-bis(tetrahydropyranyloxy)-23,24-dinor-6-cholene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 110-87-2
3,4-dihydro-2H-pyran

: 131249-29-1
22-Phenylsulfonyl-5α,8α-(4-phenyl-3,5-dioxo-1,2,4-triazolidine-1,2-diyl)-23,24-dinor-6-cholene-1α,3β-diol

: 131249-30-4
22-Phenylsulfonyl-5α,8α-(4-phenyl-3,5-dioxo-1,2,4-triazolidine-1,2-diyl)-1α,3β-bis(tetrahydropyranyloxy)-23,24-dinor-6-cholene

Guidance literature:: With pyridinium p-toluenesulfonate; In dichloromethane; for 24h; Ambient temperature;
DOI:10.1246/bcsj.63.2233

Reference yield:

: 873-55-2
sodium benzenesulfonate

: 131249-30-4
22-Phenylsulfonyl-5α,8α-(4-phenyl-3,5-dioxo-1,2,4-triazolidine-1,2-diyl)-1α,3β-bis(tetrahydropyranyloxy)-23,24-dinor-6-cholene

Guidance literature:: Multi-step reaction with 3 steps

1: 1) NaI / 1) DMF, 30 min, 80 deg C, 2) 30 min, 80 deg C

2: 79 percent / KOH / methanol / 0.5 h / Heating

3: 90 percent / PPTS / CH₂Cl₂ / 24 h / Ambient temperature

With potassium hydroxide; pyridinium p-toluenesulfonate; sodium iodide; In methanol; dichloromethane;
DOI:10.1246/bcsj.63.2233

Reference yield:

: 125315-55-1
22-hydroxy-5α,8α-(4-phenyl-3,5-dioxo-1,2,4-triazolidine-1,2-diyl)-23,24-dinorchol-6-ene-1α,3β-diol 1,3-diacetate

: 131249-30-4
22-Phenylsulfonyl-5α,8α-(4-phenyl-3,5-dioxo-1,2,4-triazolidine-1,2-diyl)-1α,3β-bis(tetrahydropyranyloxy)-23,24-dinor-6-cholene

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine / 4 h / Ambient temperature

2: 1) NaI / 1) DMF, 30 min, 80 deg C, 2) 30 min, 80 deg C

3: 79 percent / KOH / methanol / 0.5 h / Heating

4: 90 percent / PPTS / CH₂Cl₂ / 24 h / Ambient temperature

With pyridine; potassium hydroxide; pyridinium p-toluenesulfonate; sodium iodide; In methanol; dichloromethane;
DOI:10.1246/bcsj.63.2233