(R)-tert-butyl benzyl(5-((1-((tert-butyldimethylsilyl)oxy)butan-2-yl)amino)-3-isopropylpyrazolo[1,5-a]pyrimidin-7-yl)carbamate

Base Information

• Chemical Name: (R)-tert-butyl benzyl(5-((1-((tert-butyldimethylsilyl)oxy)butan-2-yl)amino)-3-isopropylpyrazolo[1,5-a]pyrimidin-7-yl)carbamate
• CAS No.: 1256288-43-3
• Molecular Formula: C₃₁H₄₉N₅O₃Si
• Molecular Weight: 567.847
• Mol file: 1256288-43-3.mol

Synonyms:(R)-tert-butyl benzyl(5-((1-((tert-butyldimethylsilyl)oxy)butan-2-yl)amino)-3-isopropylpyrazolo[1,5-a]pyrimidin-7-yl)carbamate

Chemical Property of (R)-tert-butyl benzyl(5-((1-((tert-butyldimethylsilyl)oxy)butan-2-yl)amino)-3-isopropylpyrazolo[1,5-a]pyrimidin-7-yl)carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-tert-butyl benzyl(5-((1-((tert-butyldimethylsilyl)oxy)butan-2-yl)amino)-3-isopropylpyrazolo[1,5-a]pyrimidin-7-yl)carbamate

There total 1 articles about (R)-tert-butyl benzyl(5-((1-((tert-butyldimethylsilyl)oxy)butan-2-yl)amino)-3-isopropylpyrazolo[1,5-a]pyrimidin-7-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

(R)-tert-butyl benzyl(5-((1-((tert-butyldimethylsilyl)oxy)but-3-en-2-yl)amino)-3-iso-propylpyrazolo[1,5-a]pyrimidin-7-yl)carbamate (1092444-50-2) → (R)-tert-butyl benzyl(5-((1-((tert-butyldimethylsilyl)oxy)butan-2-yl)amino)-3-isopropylpyrazolo[1,5-a]pyrimidin-7-yl)carbamate (1256288-43-3)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethyl acetate; for 12h;

DOI:10.1021/jm100732t

Reference yield: 94.0%

(R)-tert-butyl benzyl(5-((1-((tert-butyldimethylsilyl)oxy)butan-2-yl)amino)-3-isopropylpyrazolo[1,5-a]pyrimidin-7-yl)carbamate (1256288-43-3) → (R)-2-((7-(benzylamino)-3-iso-propylpyrazolo[1,5-a]pyrimidin-5-yl)amino)butan-1-ol (1092443-53-2)

Guidance literature:

With hydrogenchloride; In methanol; water; at 25 ℃; for 3h;

DOI:10.1021/jm100732t

upstream raw materials:

(R)-tert-butyl benzyl(5-((1-((tert-butyldimethylsilyl)oxy)but-3-en-2-yl)amino)-3-iso-propylpyrazolo[1,5-a]pyrimidin-7-yl)carbamate

Downstream raw materials:

(R)-2-((7-(benzylamino)-3-iso-propylpyrazolo[1,5-a]pyrimidin-5-yl)amino)butan-1-ol