7-bromo-3-[4-(2-methyl-3-phenyl-2(E)-propen-1-yl)piperazin-1-ylmethyl]-3a,4-dihydro-3H-[1]benzopyrano[4,3-c]isoxazole

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Chemical Name:7-bromo-3-[4-(2-methyl-3-phenyl-2(E)-propen-1-yl)piperazin-1-ylmethyl]-3a,4-dihydro-3H-[1]benzopyrano[4,3-c]isoxazole
CAS No.:1055723-14-2
Molecular Formula:C₂₅H₂₈BrN₃O₂
Molecular Weight:482.42
Hs Code.:

Synonyms:7-bromo-3-[4-(2-methyl-3-phenyl-2(E)-propen-1-yl)piperazin-1-ylmethyl]-3a,4-dihydro-3H-[1]benzopyrano[4,3-c]isoxazole

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Chemical Property of 7-bromo-3-[4-(2-methyl-3-phenyl-2(E)-propen-1-yl)piperazin-1-ylmethyl]-3a,4-dihydro-3H-[1]benzopyrano[4,3-c]isoxazole

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Technology Process of 7-bromo-3-[4-(2-methyl-3-phenyl-2(E)-propen-1-yl)piperazin-1-ylmethyl]-3a,4-dihydro-3H-[1]benzopyrano[4,3-c]isoxazole

There total 6 articles about 7-bromo-3-[4-(2-methyl-3-phenyl-2(E)-propen-1-yl)piperazin-1-ylmethyl]-3a,4-dihydro-3H-[1]benzopyrano[4,3-c]isoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: N-(2-methyl-3-phenyl-2(E)-propen-1-yl)piperazine

: methanesulfonic acid 7-bromo-3a,4-dihydro-3H-chromeno[4,3-c]isoxazol-3-ylmethyl ester

: 1055723-14-2
7-bromo-3-[4-(2-methyl-3-phenyl-2(E)-propen-1-yl)piperazin-1-ylmethyl]-3a,4-dihydro-3H-[1]benzopyrano[4,3-c]isoxazole

Guidance literature:: With potassium carbonate; potassium iodide; In various solvent(s); for 24h; Heating;
DOI:10.1016/j.bmc.2006.02.043

Reference yield:

: (7-bromo-3a,4-dihydro-3H-chromeno[4,3-c]isoxazol-3-yl)-methanol

: 1055723-14-2
7-bromo-3-[4-(2-methyl-3-phenyl-2(E)-propen-1-yl)piperazin-1-ylmethyl]-3a,4-dihydro-3H-[1]benzopyrano[4,3-c]isoxazole

Guidance literature:: Multi-step reaction with 2 steps

1: 4.06 g / triethylamine / CH₂Cl₂ / 2 h / 0 °C

2: 46 percent / K₂CO₃; KI / various solvent(s) / 24 h / Heating

With potassium carbonate; triethylamine; potassium iodide; In dichloromethane;
DOI:10.1016/j.bmc.2006.02.043

Reference yield:

: 888728-15-2
ethyl 4-(2-formyl-5-bromophenoxy)but-2(E)-enoate

: 1055723-14-2
7-bromo-3-[4-(2-methyl-3-phenyl-2(E)-propen-1-yl)piperazin-1-ylmethyl]-3a,4-dihydro-3H-[1]benzopyrano[4,3-c]isoxazole

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydroxylamine hydrochloride; sodium acetate / ethanol / 2 h / 20 °C

2.1: sodium hypochlorite / CH₂Cl₂; H₂O / 2 h / 20 °C

2.2: 1.71 g / triethylamine / CH₂Cl₂; H₂O / 24 h / 20 °C

3.1: sodium borohydride / tetrahydrofuran; H₂O / 24 h / 20 °C

4.1: 4.06 g / triethylamine / CH₂Cl₂ / 2 h / 0 °C

5.1: 46 percent / K₂CO₃; KI / various solvent(s) / 24 h / Heating

With sodium hypochlorite; sodium tetrahydroborate; hydroxylamine hydrochloride; sodium acetate; potassium carbonate; triethylamine; potassium iodide; In tetrahydrofuran; ethanol; dichloromethane; water;
DOI:10.1016/j.bmc.2006.02.043