ethyl N-[4-[2-[[(1S, 2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methyl-ethyl]amino]ethyl]phenyl]-N-methylaminoacetate

Base Information

Chemical Name:ethyl N-[4-[2-[[(1S, 2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methyl-ethyl]amino]ethyl]phenyl]-N-methylaminoacetate
CAS No.:227467-79-0
Molecular Formula:C₂₂H₃₀N₂O₄
Molecular Weight:386.491
Hs Code.:

Synonyms:ethyl N-[4-[2-[[(1S, 2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methyl-ethyl]amino]ethyl]phenyl]-N-methylaminoacetate

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Chemical Property of ethyl N-[4-[2-[[(1S, 2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methyl-ethyl]amino]ethyl]phenyl]-N-methylaminoacetate

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Technology Process of ethyl N-[4-[2-[[(1S, 2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methyl-ethyl]amino]ethyl]phenyl]-N-methylaminoacetate

There total 4 articles about ethyl N-[4-[2-[[(1S, 2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methyl-ethyl]amino]ethyl]phenyl]-N-methylaminoacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 552-85-2,771-91-5,1926-72-3,13104-32-0,37692-93-6,52446-53-4,62928-85-2,62928-86-3,73027-12-0
4-((1R,2S)-2-amino-1-hydroxypropyl)phenol

: 344285-72-9
ethyl N-[4-(2-bromoethyl)phenyl]-N-methylaminoacetate

: 227467-79-0
ethyl N-[4-[2-[[(1S, 2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methyl-ethyl]amino]ethyl]phenyl]-N-methylaminoacetate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 70 ℃; for 7h;
DOI:10.1021/jm000455z

Reference yield:

: 227467-47-2
ethyl N-[4-(2-hydroxyethyl)phenyl]aminoacetate

: 227467-79-0
ethyl N-[4-[2-[[(1S, 2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methyl-ethyl]amino]ethyl]phenyl]-N-methylaminoacetate

Guidance literature:: Multi-step reaction with 3 steps

1: 67 percent / K₂CO₃ / dimethylformamide / 9 h / 20 °C

2: Ph₃P; CBr₄ / CH₂Cl₂ / 1 h

3: N,N-diisopropylethylamine / dimethylformamide / 7 h / 70 °C

With carbon tetrabromide; potassium carbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm000455z

Reference yield:

: 227467-55-2
ethyl N-[4-(2-hydroxyethyl)phenyl]-N-methylaminoacetate

: 227467-79-0
ethyl N-[4-[2-[[(1S, 2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methyl-ethyl]amino]ethyl]phenyl]-N-methylaminoacetate

Guidance literature:: Multi-step reaction with 2 steps

1: Ph₃P; CBr₄ / CH₂Cl₂ / 1 h

2: N,N-diisopropylethylamine / dimethylformamide / 7 h / 70 °C

With carbon tetrabromide; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm000455z