3-cyclohexyl-3-hydroxy-2-methyl-thiopropionic acid S-phenyl ester

Base Information

• Chemical Name: 3-cyclohexyl-3-hydroxy-2-methyl-thiopropionic acid S-phenyl ester
• CAS No.: 127422-21-3
• Molecular Formula: C₁₆H₂₂O₂S
• Molecular Weight: 278.415
• Mol file: 127422-21-3.mol

Synonyms:3-cyclohexyl-3-hydroxy-2-methyl-thiopropionic acid S-phenyl ester

Chemical Property of 3-cyclohexyl-3-hydroxy-2-methyl-thiopropionic acid S-phenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 3-cyclohexyl-3-hydroxy-2-methyl-thiopropionic acid S-phenyl ester

There total 7 articles about 3-cyclohexyl-3-hydroxy-2-methyl-thiopropionic acid S-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

rac-2-methyl-3-oxo-3-(phenylthio)propanoic acid (30409-97-3) + cyclohexanecarbaldehyde (2043-61-0) → 3-cyclohexyl-3-hydroxy-2-methyl-thiopropionic acid S-phenyl ester + 3-cyclohexyl-3-hydroxy-2-methyl-thiopropionic acid S-phenyl ester (127422-21-3,127422-23-5) + 3-cyclohexyl-3-hydroxy-2-methyl-thiopropionic acid S-phenyl ester (127422-21-3)

Guidance literature:

With copper(II) bis(trifluoromethanesulfonate); (4R,4'R)-2,2'-(propane-2,2'diyl)bis(4-phenyl-4,5-dihydrooxazole); In acetone; toluene; at 23 ℃; for 60h; Title compound not separated from byproducts;

DOI:10.1021/ja051759j

Reference yield:

rac-2-methyl-3-oxo-3-(phenylthio)propanoic acid (30409-97-3) + cyclohexanecarbaldehyde (2043-61-0) → 3-cyclohexyl-3-hydroxy-2-methyl-thiopropionic acid S-phenyl ester + 3-cyclohexyl-3-hydroxy-2-methyl-thiopropionic acid S-phenyl ester (127422-21-3,127422-23-5) + 3-cyclohexyl-3-hydroxy-2-methyl-thiopropionic acid S-phenyl ester (127422-21-3)

Guidance literature:

With copper(II) bis(trifluoromethanesulfonate); (4R,4'R)-2,2'-(propane-2,2'diyl)bis(4-phenyl-4,5-dihydrooxazole); In acetone; toluene; at 23 ℃; for 60h; Title compound not separated from byproducts;

DOI:10.1021/ja051759j

Reference yield:

thiophenol (108-98-5) → 3-cyclohexyl-3-hydroxy-2-methyl-thiopropionic acid S-phenyl ester (127422-21-3,127422-23-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: iPr₂NEt; TMSCl / acetonitrile / 0.25 h / 0 °C

1.2: 94 percent / acetonitrile / 12 h / 43 °C

2.1: Cu(OTf)2; (R)-(+)-(2,2)-isopropylidenebis(4-phenyl-2-oxazoline) / toluene; acetone / 60 h / 23 °C

With chloro-trimethyl-silane; copper(II) bis(trifluoromethanesulfonate); N-ethyl-N,N-diisopropylamine; (4R,4'R)-2,2'-(propane-2,2'diyl)bis(4-phenyl-4,5-dihydrooxazole); In acetone; toluene; acetonitrile;

DOI:10.1021/ja051759j

upstream raw materials:

S-phenylthiopropionate

cyclohexanecarbaldehyde

rac-2-methyl-3-oxo-3-(phenylthio)propanoic acid

thiophenol