{(1R)-2-[(1R)-3-oxo-2,3-dihydro-1H-isoindol-1-yl]-1-(4-methylphenyl)ethyl} benzoate

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Chemical Name:{(1R)-2-[(1R)-3-oxo-2,3-dihydro-1H-isoindol-1-yl]-1-(4-methylphenyl)ethyl} benzoate
CAS No.:1338225-80-1
Molecular Formula:C₂₄H₂₁NO₃
Molecular Weight:371.436
Hs Code.:

Synonyms:{(1R)-2-[(1R)-3-oxo-2,3-dihydro-1H-isoindol-1-yl]-1-(4-methylphenyl)ethyl} benzoate

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Chemical Property of {(1R)-2-[(1R)-3-oxo-2,3-dihydro-1H-isoindol-1-yl]-1-(4-methylphenyl)ethyl} benzoate

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Technology Process of {(1R)-2-[(1R)-3-oxo-2,3-dihydro-1H-isoindol-1-yl]-1-(4-methylphenyl)ethyl} benzoate

There total 3 articles about {(1R)-2-[(1R)-3-oxo-2,3-dihydro-1H-isoindol-1-yl]-1-(4-methylphenyl)ethyl} benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 1338225-77-6
(3R)-3-[(2S)-2-hydroxy-2-(4-methylphenyl)ethyl]-2,3-dihydro-1H-isoindol-1-one

: 65-85-0,8013-63-6
benzoic acid

: 1338225-80-1
{(1R)-2-[(1R)-3-oxo-2,3-dihydro-1H-isoindol-1-yl]-1-(4-methylphenyl)ethyl} benzoate

Guidance literature:: benzoic acid; With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 ℃; for 0.5h; Inert atmosphere;

(3R)-3-[(2S)-2-hydroxy-2-(4-methylphenyl)ethyl]-2,3-dihydro-1H-isoindol-1-one; In tetrahydrofuran; at 0 ℃; Inert atmosphere;
DOI:10.1016/j.bmcl.2011.07.119

Reference yield:

: 944052-53-3
(3R)-3-[2-(4-methylphenyl)-2-oxoethyl]-2-[(1S,5R)-5,8,8-trimethyl-2-oxo-3-oxabicyclo[3.2.1]octane-1-carbonyl]-2,3-dihydroisoindol-1-one

: 1338225-80-1
{(1R)-2-[(1R)-3-oxo-2,3-dihydro-1H-isoindol-1-yl]-1-(4-methylphenyl)ethyl} benzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: Li[Al(tBuO)3H] / tetrahydrofuran / 16 h / 0 °C / Inert atmosphere

2.1: lithium borohydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

3.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

3.2: 0 °C / Inert atmosphere

With lithium borohydride; di-isopropyl azodicarboxylate; Li[Al(tBuO)3H]; triphenylphosphine; In tetrahydrofuran; 3.1: Mitsunobu reaction / 3.2: Mitsunobu reaction;
DOI:10.1016/j.bmcl.2011.07.119

Reference yield:

: 1338225-74-3
(3R)-3-[(2S)-2-hydroxy-2-(4-methylphenyl)ethyl]-2-[(1S,5R)-5,8,8-trimethyl-2-oxo-3-oxabicyclo[3.2.1]octane-1-carbonyl]-2,3-dihydroisoindol-1-one

: 1338225-80-1
{(1R)-2-[(1R)-3-oxo-2,3-dihydro-1H-isoindol-1-yl]-1-(4-methylphenyl)ethyl} benzoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium borohydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

2.2: 0 °C / Inert atmosphere

With lithium borohydride; di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; 2.1: Mitsunobu reaction / 2.2: Mitsunobu reaction;
DOI:10.1016/j.bmcl.2011.07.119