tert-butyl {(2S)-1-amino-1-oxo-2-[3-(trifluoromethyl)phenyl]propan-2-yl}carbamate

Base Information

Chemical Name:tert-butyl {(2S)-1-amino-1-oxo-2-[3-(trifluoromethyl)phenyl]propan-2-yl}carbamate
CAS No.:1245940-54-8
Molecular Formula:C₁₅H₁₉F₃N₂O₃
Molecular Weight:332.323
Hs Code.:

Synonyms:tert-butyl {(2S)-1-amino-1-oxo-2-[3-(trifluoromethyl)phenyl]propan-2-yl}carbamate

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Chemical Property of tert-butyl {(2S)-1-amino-1-oxo-2-[3-(trifluoromethyl)phenyl]propan-2-yl}carbamate

Chemical Property:

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Technology Process of tert-butyl {(2S)-1-amino-1-oxo-2-[3-(trifluoromethyl)phenyl]propan-2-yl}carbamate

There total 3 articles about tert-butyl {(2S)-1-amino-1-oxo-2-[3-(trifluoromethyl)phenyl]propan-2-yl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1245940-52-6
tert-Butyl {1-amino-1-oxo-2-[3-(trifluoromethyl)phenyl]propan-2-yl}carbamate

: 1245940-54-8
tert-butyl {(2S)-1-amino-1-oxo-2-[3-(trifluoromethyl)phenyl]propan-2-yl}carbamate

Guidance literature:: With silica gel; In methanol; ethyl acetate; Purification / work up; Resolution of racemate;

Reference yield:

: 1183104-54-2
2-amino-2-[3-(trifluoromethyl)phenyl]propanamide

: 1245940-54-8
tert-butyl {(2S)-1-amino-1-oxo-2-[3-(trifluoromethyl)phenyl]propan-2-yl}carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydrogencarbonate / N,N-dimethyl-formamide; tert-butyl alcohol / 72 h / 60 °C

2: silica gel / ethyl acetate; methanol / Resolution of racemate

With sodium hydrogencarbonate; In methanol; ethyl acetate; N,N-dimethyl-formamide; tert-butyl alcohol;

Reference yield:

: 953741-94-1
2-amino-2-[3-(trifluoromethyl)phenyl]propionitrile

: 1245940-54-8
tert-butyl {(2S)-1-amino-1-oxo-2-[3-(trifluoromethyl)phenyl]propan-2-yl}carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride; water / 20 °C / Cooling with ice

2: sodium hydrogencarbonate / N,N-dimethyl-formamide; tert-butyl alcohol / 72 h / 60 °C

3: silica gel / ethyl acetate; methanol / Resolution of racemate

With hydrogenchloride; water; sodium hydrogencarbonate; In methanol; ethyl acetate; N,N-dimethyl-formamide; tert-butyl alcohol;