(R)-3-(4-(7H-pyrrolo[2,3-c]pyridazin-4-yl)-1H-pyrazol-1-yl)-3-phenylpropane nitrile

Base Information

Chemical Name:(R)-3-(4-(7H-pyrrolo[2,3-c]pyridazin-4-yl)-1H-pyrazol-1-yl)-3-phenylpropane nitrile
CAS No.:1269823-77-9
Molecular Formula:C₁₈H₁₄N₆
Molecular Weight:314.349
Hs Code.:

Synonyms:(R)-3-(4-(7H-pyrrolo[2,3-c]pyridazin-4-yl)-1H-pyrazol-1-yl)-3-phenylpropane nitrile

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Chemical Property of (R)-3-(4-(7H-pyrrolo[2,3-c]pyridazin-4-yl)-1H-pyrazol-1-yl)-3-phenylpropane nitrile

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Technology Process of (R)-3-(4-(7H-pyrrolo[2,3-c]pyridazin-4-yl)-1H-pyrazol-1-yl)-3-phenylpropane nitrile

There total 14 articles about (R)-3-(4-(7H-pyrrolo[2,3-c]pyridazin-4-yl)-1H-pyrazol-1-yl)-3-phenylpropane nitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 19.0%

: 1269823-78-0
(R)-(4-(1-(2-cyano-1-phenylethyl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-c]pyridazin-7-yl)methyl pivalate

: 1269823-77-9
(R)-3-(4-(7H-pyrrolo[2,3-c]pyridazin-4-yl)-1H-pyrazol-1-yl)-3-phenylpropane nitrile

Guidance literature:: With sodium hydroxide; In methanol; at 20 ℃; for 6h;

Reference yield:

: 1269822-93-6
1-(4-acetyl-5-nitro-1H-pyrrol-2-yl)-2,2,2-trichloroethanone

: 1269823-77-9
(R)-3-(4-(7H-pyrrolo[2,3-c]pyridazin-4-yl)-1H-pyrazol-1-yl)-3-phenylpropane nitrile

Guidance literature:: Multi-step reaction with 12 steps

1.1: methanol / 0.5 h / 20 °C

1.2: 20 °C

2.1: acetic acid; iron / 0.5 h / 45 - 100 °C

3.1: sodium nitrite / water; acetic acid / 48 h / 18 - 65 °C

4.1: potassium hydroxide / 0.5 h / 70 °C

4.2: 20 °C

5.1: trifluoroacetic acid / 48 h / 230 °C / Sealed ampoule

6.1: trichlorophosphate; N-benzyl-N,N,N-triethylammonium chloride; N,N-dimethyl-aniline / acetonitrile / 2 h / 80 °C

7.1: dmap; triethylamine / dichloromethane / -10 - 50 °C

8.1: potassium carbonate; water / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 2 h / 80 °C / Inert atmosphere

9.1: hydrogenchloride / water; tetrahydrofuran / 10 h / 20 °C

10.1: 4-nitro-benzoic acid; (R)-(-)-α,α-bis[3,5-bis(trifluoromethyl)phenyl]-2-pyrrolidinemethanoltrimethylsilyl ether / chloroform / 20 °C

11.1: ammonium hydroxide; iodine / tetrahydrofuran / 1 h / 20 °C

11.2: 20 °C

12.1: sodium hydroxide / methanol / 6 h / 20 °C

With hydrogenchloride; dmap; ammonium hydroxide; (R)-(-)-α,α-bis[3,5-bis(trifluoromethyl)phenyl]-2-pyrrolidinemethanoltrimethylsilyl ether; N-benzyl-N,N,N-triethylammonium chloride; water; iodine; iron; potassium carbonate; acetic acid; N,N-dimethyl-aniline; triethylamine; trifluoroacetic acid; potassium hydroxide; sodium hydroxide; sodium nitrite; trichlorophosphate; 4-nitro-benzoic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; chloroform; water; acetic acid; acetonitrile;

Reference yield:

: 1269822-94-7
methyl 4-acetyl-5-nitro-1H-pyrrole-2-carboxylate

: 1269823-77-9
(R)-3-(4-(7H-pyrrolo[2,3-c]pyridazin-4-yl)-1H-pyrazol-1-yl)-3-phenylpropane nitrile

Guidance literature:: Multi-step reaction with 11 steps

1.1: acetic acid; iron / 0.5 h / 45 - 100 °C

2.1: sodium nitrite / water; acetic acid / 48 h / 18 - 65 °C

3.1: potassium hydroxide / 0.5 h / 70 °C

3.2: 20 °C

4.1: trifluoroacetic acid / 48 h / 230 °C / Sealed ampoule

5.1: trichlorophosphate; N-benzyl-N,N,N-triethylammonium chloride; N,N-dimethyl-aniline / acetonitrile / 2 h / 80 °C

6.1: dmap; triethylamine / dichloromethane / -10 - 50 °C

7.1: potassium carbonate; water / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 2 h / 80 °C / Inert atmosphere

8.1: hydrogenchloride / water; tetrahydrofuran / 10 h / 20 °C

9.1: 4-nitro-benzoic acid; (R)-(-)-α,α-bis[3,5-bis(trifluoromethyl)phenyl]-2-pyrrolidinemethanoltrimethylsilyl ether / chloroform / 20 °C

10.1: ammonium hydroxide; iodine / tetrahydrofuran / 1 h / 20 °C

10.2: 20 °C

11.1: sodium hydroxide / methanol / 6 h / 20 °C

With hydrogenchloride; dmap; ammonium hydroxide; (R)-(-)-α,α-bis[3,5-bis(trifluoromethyl)phenyl]-2-pyrrolidinemethanoltrimethylsilyl ether; N-benzyl-N,N,N-triethylammonium chloride; water; iodine; iron; potassium carbonate; acetic acid; N,N-dimethyl-aniline; triethylamine; trifluoroacetic acid; potassium hydroxide; sodium hydroxide; sodium nitrite; trichlorophosphate; 4-nitro-benzoic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; chloroform; water; acetic acid; acetonitrile;