3-(2-hydroxy-5-(ethoxy(diethylphosphonomethyl)phosphinoyl)phenyl)-3-methylbutanoic acid

Base Information

• Chemical Name: 3-(2-hydroxy-5-(ethoxy(diethylphosphonomethyl)phosphinoyl)phenyl)-3-methylbutanoic acid
• CAS No.: 925685-07-0
• Molecular Formula: C₁₈H₃₀O₈P₂
• Molecular Weight: 436.379
• Mol file: 925685-07-0.mol

Synonyms:3-(2-hydroxy-5-(ethoxy(diethylphosphonomethyl)phosphinoyl)phenyl)-3-methylbutanoic acid

Chemical Property of 3-(2-hydroxy-5-(ethoxy(diethylphosphonomethyl)phosphinoyl)phenyl)-3-methylbutanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(2-hydroxy-5-(ethoxy(diethylphosphonomethyl)phosphinoyl)phenyl)-3-methylbutanoic acid

There total 3 articles about 3-(2-hydroxy-5-(ethoxy(diethylphosphonomethyl)phosphinoyl)phenyl)-3-methylbutanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

6-(ethoxy(diethylphosphonomethyl)phosphinoyl)-3,4-dihydro-4,4-dimethylchromen-2-one (925685-06-9) → 3-(2-hydroxy-5-(ethoxy(diethylphosphonomethyl)phosphinoyl)phenyl)-3-methylbutanoic acid (925685-07-0)

Guidance literature:

6-(ethoxy(diethylphosphonomethyl)phosphinoyl)-3,4-dihydro-4,4-dimethylchromen-2-one; With methanol; potassium hydroxide; at 20 ℃; for 2h;

With hydrogenchloride; In methanol; dichloromethane; water; pH=4;

Reference yield:

4,4-dimethyl-6-bromo-2-oxo-chroman (164012-31-1) → 3-(2-hydroxy-5-(ethoxy(diethylphosphonomethyl)phosphinoyl)phenyl)-3-methylbutanoic acid (925685-07-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: triethylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / acetonitrile / 18 h / 100 °C

2.1: potassium hydroxide / methanol / 2 h / 20 °C

2.2: pH 4

With potassium hydroxide; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; acetonitrile;

Reference yield:

diethyl 1-(ethoxyphosphinyl)methylphosphonate (179015-82-8) → 3-(2-hydroxy-5-(ethoxy(diethylphosphonomethyl)phosphinoyl)phenyl)-3-methylbutanoic acid (925685-07-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: triethylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / acetonitrile / 18 h / 100 °C

2.1: potassium hydroxide / methanol / 2 h / 20 °C

2.2: pH 4

With potassium hydroxide; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; acetonitrile;

upstream raw materials:

6-(ethoxy(diethylphosphonomethyl)phosphinoyl)-3,4-dihydro-4,4-dimethylchromen-2-one

4,4-dimethyl-6-bromo-2-oxo-chroman

diethyl 1-(ethoxyphosphinyl)methylphosphonate

Downstream raw materials:

benzyl 3-(2-hydroxy-5-(ethoxy(diethylphosphonomethyl)phosphinoyl)phenyl)-3-methylbutanoate

3-(2-acetoxy-5-(ethoxy(diethylphosphonomethyl)phosphinoyl)phenyl)-3-methylbutanoic acid

3-(2-(2,2-dimethylacetoxy)-5-(ethoxy(diethylphosphonomethyl)phosphinoyl)phenyl)-3-methylbutanoic acid

3-(2-butyroxy-5-(ethoxy(diethylphosphonomethyl)phosphinoyl)phenyl)-3-methylbutanoic acid