N-(4-benzyloxycarbonylamidino-benzyl)-2-[4-(3-nitro-phenylamino)-3-oxo-morpholin-2-yl]-acetamide acid benzyl ester

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Chemical Name:N-(4-benzyloxycarbonylamidino-benzyl)-2-[4-(3-nitro-phenylamino)-3-oxo-morpholin-2-yl]-acetamide acid benzyl ester
CAS No.:609846-74-4
Molecular Formula:C₂₈H₂₈N₆O₇
Molecular Weight:560.566
Hs Code.:

Synonyms:N-(4-benzyloxycarbonylamidino-benzyl)-2-[4-(3-nitro-phenylamino)-3-oxo-morpholin-2-yl]-acetamide acid benzyl ester

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Chemical Property of N-(4-benzyloxycarbonylamidino-benzyl)-2-[4-(3-nitro-phenylamino)-3-oxo-morpholin-2-yl]-acetamide acid benzyl ester

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Technology Process of N-(4-benzyloxycarbonylamidino-benzyl)-2-[4-(3-nitro-phenylamino)-3-oxo-morpholin-2-yl]-acetamide acid benzyl ester

There total 6 articles about N-(4-benzyloxycarbonylamidino-benzyl)-2-[4-(3-nitro-phenylamino)-3-oxo-morpholin-2-yl]-acetamide acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 441764-54-1
(S)-2-(2-oxo-ethoxy)-succinic acid dimethyl ester

: 609846-74-4
N-(4-benzyloxycarbonylamidino-benzyl)-2-[4-(3-nitro-phenylamino)-3-oxo-morpholin-2-yl]-acetamide acid benzyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 97 percent / toluene / 65 °C

2: 100 percent / H₂ / Pd/C / tetrahydrofuran / 18 h

3: 77 percent / H₂O / 7 h / 60 °C

4: 33 percent / Pd(OAc)2; 9,9-dimethyl-4,5-bis(diphenylphosphino)xanthene; Cs₂CO₃ / toluene / 19 h / 95 °C

5: aq. LiOH / methanol

6: 0.018 g / O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium PF₆; DIPEA / dimethylformamide / 1.67 h

With palladium diacetate; lithium hydroxide; water; hydrogen; caesium carbonate; N-ethyl-N,N-diisopropylamine; HATU; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm0307990

Reference yield:

: (S)-[2-(tert-butoxycarbonyl-hydrazono)-ethoxy]-succinic acid dimethyl ester

: 609846-74-4
N-(4-benzyloxycarbonylamidino-benzyl)-2-[4-(3-nitro-phenylamino)-3-oxo-morpholin-2-yl]-acetamide acid benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 100 percent / H₂ / Pd/C / tetrahydrofuran / 18 h

2: 77 percent / H₂O / 7 h / 60 °C

3: 33 percent / Pd(OAc)2; 9,9-dimethyl-4,5-bis(diphenylphosphino)xanthene; Cs₂CO₃ / toluene / 19 h / 95 °C

4: aq. LiOH / methanol

5: 0.018 g / O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium PF₆; DIPEA / dimethylformamide / 1.67 h

With palladium diacetate; lithium hydroxide; water; hydrogen; caesium carbonate; N-ethyl-N,N-diisopropylamine; HATU; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm0307990

Reference yield:

: 609846-34-6
[(S)-4-amino-3-oxo-morpholin-2-yl]-acetic acid methyl ester

: 609846-74-4
N-(4-benzyloxycarbonylamidino-benzyl)-2-[4-(3-nitro-phenylamino)-3-oxo-morpholin-2-yl]-acetamide acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 33 percent / Pd(OAc)2; 9,9-dimethyl-4,5-bis(diphenylphosphino)xanthene; Cs₂CO₃ / toluene / 19 h / 95 °C

2: aq. LiOH / methanol

3: 0.018 g / O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium PF₆; DIPEA / dimethylformamide / 1.67 h

With palladium diacetate; lithium hydroxide; caesium carbonate; N-ethyl-N,N-diisopropylamine; HATU; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In methanol; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm0307990