N'-[(3-fluoro-4-chlorophenyl)methylene]-(4-oxo-6,7-dihydro-5H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-3(4H)-yl)acetohydrazone

Base Information

• Chemical Name: N'-[(3-fluoro-4-chlorophenyl)methylene]-(4-oxo-6,7-dihydro-5H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-3(4H)-yl)acetohydrazone
• CAS No.: 1345512-61-9
• Molecular Formula: C₁₈H₁₄ClFN₄O₂S
• Molecular Weight: 404.852
• Mol file: 1345512-61-9.mol

Synonyms:N'-[(3-fluoro-4-chlorophenyl)methylene]-(4-oxo-6,7-dihydro-5H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-3(4H)-yl)acetohydrazone

Chemical Property of N'-[(3-fluoro-4-chlorophenyl)methylene]-(4-oxo-6,7-dihydro-5H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-3(4H)-yl)acetohydrazone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N'-[(3-fluoro-4-chlorophenyl)methylene]-(4-oxo-6,7-dihydro-5H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-3(4H)-yl)acetohydrazone

There total 5 articles about N'-[(3-fluoro-4-chlorophenyl)methylene]-(4-oxo-6,7-dihydro-5H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-3(4H)-yl)acetohydrazone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C11H12N4O2S (1345512-97-1) + 4-chloro-3-fluorobenzaldehyde (5527-95-7) → N'-[(3-fluoro-4-chlorophenyl)methylene]-(4-oxo-6,7-dihydro-5H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-3(4H)-yl)acetohydrazone (1345512-61-9)

Guidance literature:

In butan-1-ol; at 110 ℃; for 12h;

DOI:10.1016/j.bmcl.2011.09.061

Reference yield:

ethyl 2-amino-4H,5H,6H-cyclopentenothiophene-3-carboxylate (4815-29-6) → N'-[(3-fluoro-4-chlorophenyl)methylene]-(4-oxo-6,7-dihydro-5H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-3(4H)-yl)acetohydrazone (1345512-61-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.5 h / 200 °C

2: potassium carbonate / acetone / 48 h / 55 °C

3: hydrazine / ethanol / 12 h / Reflux

4: butan-1-ol / 12 h / 110 °C

With potassium carbonate; hydrazine; In ethanol; acetone; butan-1-ol;

DOI:10.1016/j.bmcl.2011.09.061

Reference yield:

C13H14N2O3S (433702-79-5) → N'-[(3-fluoro-4-chlorophenyl)methylene]-(4-oxo-6,7-dihydro-5H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-3(4H)-yl)acetohydrazone (1345512-61-9)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrazine / ethanol / 12 h / Reflux

2: butan-1-ol / 12 h / 110 °C

With hydrazine; In ethanol; butan-1-ol;

DOI:10.1016/j.bmcl.2011.09.061

upstream raw materials:

ethyl 2-amino-4H,5H,6H-cyclopentenothiophene-3-carboxylate

C₁₃H₁₄N₂O₃S

C₁₁H₁₂N₄O₂S

4-chloro-3-fluorobenzaldehyde