(S)-N-{(R)-1-[4-((S)-2-methyl-butoxy)-phenyl]-2-propylamino-ethyl}-2-phenyl-propionamide

Base Information

Chemical Name:(S)-N-{(R)-1-[4-((S)-2-methyl-butoxy)-phenyl]-2-propylamino-ethyl}-2-phenyl-propionamide
CAS No.:1287286-67-2
Molecular Formula:C₂₅H₃₆N₂O₂
Molecular Weight:396.573
Hs Code.:

Synonyms:(S)-N-{(R)-1-[4-((S)-2-methyl-butoxy)-phenyl]-2-propylamino-ethyl}-2-phenyl-propionamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-N-{(R)-1-[4-((S)-2-methyl-butoxy)-phenyl]-2-propylamino-ethyl}-2-phenyl-propionamide

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Technology Process of (S)-N-{(R)-1-[4-((S)-2-methyl-butoxy)-phenyl]-2-propylamino-ethyl}-2-phenyl-propionamide

There total 10 articles about (S)-N-{(R)-1-[4-((S)-2-methyl-butoxy)-phenyl]-2-propylamino-ethyl}-2-phenyl-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

: 1287286-64-9
(2S)-N-((1R)-2-amino-1-[4-((S)-2-methylbutoxy)phenyl]-ethyl)-2-phenylpropionamide

: 123-38-6
propionaldehyde

: 1287286-67-2
(S)-N-{(R)-1-[4-((S)-2-methyl-butoxy)-phenyl]-2-propylamino-ethyl}-2-phenyl-propionamide

Guidance literature:: (2S)-N-((1R)-2-amino-1-[4-((S)-2-methylbutoxy)phenyl]-ethyl)-2-phenylpropionamide; propionaldehyde; With borane-THF; In methanol; acetic acid; at 0 ℃; for 4h;

With potassium carbonate; In methanol; water; acetic acid;

Reference yield:

: 57591-61-4,68697-60-9,127369-30-6,134694-94-3
methyl (R)-2-amino-2-(4-hydroxyphenyl)acetate hydrochloride

: 1287286-67-2
(S)-N-{(R)-1-[4-((S)-2-methyl-butoxy)-phenyl]-2-propylamino-ethyl}-2-phenyl-propionamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

2.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0 - 20 °C

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 20 °C

3.2: 1 h

4.1: triphenylphosphine; di-isopropyl azodicarboxylate / 0 - 20 °C

5.1: trifluoroacetic acid / dichloromethane / 16 h / 0 - 20 °C

5.2: 20 °C

6.1: hydrazine hydrate / ethanol / 60 °C

7.1: borane-THF / acetic acid; methanol / 4 h / 0 °C

With lithium aluminium tetrahydride; borane-THF; di-isopropyl azodicarboxylate; hydrazine hydrate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; methanol; ethanol; dichloromethane; acetic acid;

Reference yield:

: 1287286-68-3
(2S)-N-[(1R)-2-hydroxy-1-{4-[(2S)-2-methylbutoxy]phenyl}ethyl]-2-phenylpropanamide

: 1287286-67-2
(S)-N-{(R)-1-[4-((S)-2-methyl-butoxy)-phenyl]-2-propylamino-ethyl}-2-phenyl-propionamide

Guidance literature:: Multi-step reaction with 3 steps

1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 3.17 h / 0 - 20 °C

2: hydrazine hydrate / ethanol / 60 °C

3: borane-THF / acetic acid; methanol / 4 h / 0 °C

With borane-THF; di-isopropyl azodicarboxylate; hydrazine hydrate; triphenylphosphine; In tetrahydrofuran; methanol; ethanol; acetic acid;