Cefadroxil monohydrate

Base Information

• Chemical Name: Cefadroxil monohydrate
• CAS No.: 66592-87-8
• Molecular Formula: C16H17N3O5S^.H2O
• Molecular Weight: 381.409
• Hs Code.: 2941906000
• European Community (EC) Number: 629-747-6
• UNII: 280111G160
• DSSTox Substance ID: DTXSID80904597
• Wikidata: Q27124149
• NCI Thesaurus Code: C28912
• RXCUI: 2177
• Mol file: 66592-87-8.mol

Synonyms:4 Hydroxycephalexin;4-Hydroxycephalexin;5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-((amino(4-hydroxyphenyl)acetyl)amino)-3-methyl-8-oxo-, (6R-(6alpha,7beta(R*)))-;Bidocef;BL S 578;BL S578;BL-S 578;BL-S578;BLS 578;BLS578;Cefadroxil;Cefadroxil Anhydrous;Cefadroxil Monohydrate;Cephadroxyl;Duricef;S 578;S-578;S578;Ultracef

Chemical Property of Cefadroxil monohydrate

Chemical Property:

• Appearance/Colour: White crystalline solid
• Vapor Pressure: 2.71E-26mmHg at 25°C
• Melting Point: 197oC
• Boiling Point: 789.9 °C at 760 mmHg
• PKA: pKa 1.38(H2O t=20±2 N2atmosphere) (Uncertain); 7.35(H2O t=20±2 N2atmosphere) (Uncertain);10.10(H2O t=20±2 N2atmosphere) (Uncertain)
• Flash Point: 431.5 °C
• PSA: 167.49000
• LogP: 1.11530
• Storage Temp.: -20°C Freezer
• Solubility.: Slightly soluble in water, very slightly soluble in ethanol (96 per cen
• Hydrogen Bond Donor Count: 5
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 4
• Exact Mass: 381.09945651
• Heavy Atom Count: 26
• Complexity: 629

Purity/Quality:

99%, ^*data from raw suppliers

Cefadroxil monohydrate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn,Xi
• Statements: 36/37/38-42/43
• Safety Statements: 26-36-36/37

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC1=C(N2C(C(C2=O)NC(=O)C(C3=CC=C(C=C3)O)N)SC1)C(=O)O.O
• Isomeric SMILES: CC1=C(N2[C@@H]([C@@H](C2=O)NC(=O)[C@@H](C3=CC=C(C=C3)O)N)SC1)C(=O)O.O
• Recent EU Clinical Trials: Oral antimicrobial treatment vs. outpatient parenteral for infective
• Description: Cefadroxil has an amoxicillin-like side chain at C-7 and is orally active. There are some indications that cefadroxil has some immunostimulant properties mediated through T-cell activation and that this is of material assistance to patients in fighting infections. The prolonged biological half-life of cefadroxil allows once-a-day dosage.
• Uses: Semi-synthetic cephalosporin antibiotic. Antibacterial Cefadroxil Monohydrate is a semi-synthetic cephalosporin antibiotic. Antibacterial.
• Clinical Use: Cefadroxil (Duricef) is an orally active semisyntheticderivative of 7-ADCA, in which the 7-acyl group is the Dhydroxylphenylglycylmoiety. This compound is absorbedwell after oral administration to give plasma levels that reach75% to 80% of those of an equal dose of its close structuralanalog cephalexin. The main advantage claimed for cefadroxilis its somewhat prolonged duration of action, whichpermits once-a-day dosing. The prolonged duration of actionof this compound is related to relatively slow urinary excretionof the drug compared with other cephalosporins, butthe basis for this remains to be explained completely. Theantibacterial spectrum of action and therapeutic indications ofcefadroxil are very similar to those of cephalexin and cephradine.The D-p-hydroxyphenylglycyl isomer is much moreactive than the L-isomer. It has been used for various community-acquired infections for which oral cephalosporins are appropriate.
• Drug interactions: Potentially hazardous interactions with other drugs Anticoagulants: effects of coumarins may be enhanced.

Technology Process of Cefadroxil monohydrate

There total 1 articles about Cefadroxil monohydrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

→ cefadroxil monohydrate (66592-87-8)

Guidance literature:

Reference yield:

cefadroxil monohydrate (66592-87-8)

Guidance literature:

In water; at 35 ℃; Kinetics; effect of pH and temperature on degradation rate; further aminocephalosporin;

DOI:10.1248/cpb.31.4057

Refernces

• 1、 -. "Beta lactam production". . . Retrieved 2008/06/13.
• 2、 -. "Method for preparing crystalline cefadroxil monohydrate". . . Retrieved 2008/06/13.