3-(tert-Butoxycarbonylamino-ethoxycarbonyl-methyl)-benzoic acid ethyl ester

Base Information

• Chemical Name: 3-(tert-Butoxycarbonylamino-ethoxycarbonyl-methyl)-benzoic acid ethyl ester
• CAS No.: 213487-96-8
• Molecular Formula: C₁₈H₂₅NO₆
• Molecular Weight: 351.4

Synonyms:3-(tert-Butoxycarbonylamino-ethoxycarbonyl-methyl)-benzoic acid ethyl ester

Chemical Property of 3-(tert-Butoxycarbonylamino-ethoxycarbonyl-methyl)-benzoic acid ethyl ester

Chemical Property:

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Technology Process of 3-(tert-Butoxycarbonylamino-ethoxycarbonyl-methyl)-benzoic acid ethyl ester

There total 2 articles about 3-(tert-Butoxycarbonylamino-ethoxycarbonyl-methyl)-benzoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

amino-(3-carboxy-phenyl)-acetic acid (2196-57-8) → 3-(tert-Butoxycarbonylamino-ethoxycarbonyl-methyl)-benzoic acid ethyl ester (213487-96-8)

Guidance literature:

Multi-step reaction with 2 steps

1: SOCl₂ / ethanol / Heating

2: Et₃N / dimethylformamide

With thionyl chloride; triethylamine; In ethanol; N,N-dimethyl-formamide;

DOI:10.1021/jm981015z

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + 3-(Amino-ethoxycarbonyl-methyl)-benzoic acid ethyl ester → 3-(tert-Butoxycarbonylamino-ethoxycarbonyl-methyl)-benzoic acid ethyl ester (213487-96-8)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; Yield given;

DOI:10.1021/jm981015z

Reference yield:

3-(tert-Butoxycarbonylamino-ethoxycarbonyl-methyl)-benzoic acid ethyl ester (213487-96-8) → 3-(1-tert-Butoxycarbonylamino-2-hydroxy-ethyl)-benzoic acid ethyl ester

Guidance literature:

With sodium tetrahydroborate; lithium chloride; In tetrahydrofuran; ethanol; at 0 ℃;

DOI:10.1021/jm981015z

upstream raw materials:

di-tert-butyl dicarbonate

amino-(3-carboxy-phenyl)-acetic acid

Downstream raw materials:

3-(1-tert-Butoxycarbonylamino-2-hydroxy-ethyl)-benzoic acid

[1-(3-Carbamoyl-phenyl)-2-hydroxy-ethyl]-carbamic acid tert-butyl ester

[1-(3-Dimethylcarbamoyl-phenyl)-2-hydroxy-ethyl]-carbamic acid tert-butyl ester

Thioacetic acid S-[2-tert-butoxycarbonylamino-2-(3-carbamoyl-phenyl)-ethyl] ester

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