1-BOC-4-[AMINO(4-BROMOPHENYL)METHYL]-PIPERIDINE

Base Information

• Chemical Name: 1-BOC-4-[AMINO(4-BROMOPHENYL)METHYL]-PIPERIDINE
• CAS No.: 847614-88-4
• Molecular Formula: C₁₇H₂₅BrN₂O₂
• Molecular Weight: 369.302
• Mol file: 847614-88-4.mol

Synonyms:4-[amino-(4-bromo-phenyl)-methyl]-piperidine-1-carboxylic acid tert-butyl ester

Chemical Property of 1-BOC-4-[AMINO(4-BROMOPHENYL)METHYL]-PIPERIDINE

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-BOC-4-[AMINO(4-BROMOPHENYL)METHYL]-PIPERIDINE

There total 1 articles about 1-BOC-4-[AMINO(4-BROMOPHENYL)METHYL]-PIPERIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

4-(4-bromobenzoyl)piperidine-1-carboxylic acid tert-butyl ester (439811-37-7) → 4-[amino-(4-bromo-phenyl)-methyl]-piperidine-1-carboxylic acid tert-butyl ester (847614-88-4)

Guidance literature:

With ammonium acetate; sodium cyanoborohydride; In methanol; at 20 ℃;

DOI:10.1016/j.bmcl.2006.04.061

Reference yield: 57.0%

4-[amino-(4-bromo-phenyl)-methyl]-piperidine-1-carboxylic acid tert-butyl ester (847614-88-4) + (3‐cyanophenyl)boronic acid (150255-96-2) → 4-[amino-(3'-cyano-biphenyl-4-yl)-methyl]-piperidine-1-carboxylic acid tert-butyl ester (847614-89-5)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In methanol; toluene; Heating;

DOI:10.1016/j.bmcl.2006.04.061

Reference yield:

4-[amino-(4-bromo-phenyl)-methyl]-piperidine-1-carboxylic acid tert-butyl ester (847614-88-4) → 4'-{[(6-chloro-5-fluoro-1H-benzoimidazol-2-ylmethyl)-amino]-piperidin-4-yl-methyl}-biphenyl-3-carbonitrile (847614-93-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 57 percent / Pd(PPh₃)4; aq. Na₂CO₃ / toluene; methanol / Heating

2: 60 percent / K₂CO₃ / acetonitrile / 20 °C

3: 100 percent / TFA / CH₂Cl₂

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; potassium carbonate; trifluoroacetic acid; In methanol; dichloromethane; toluene; acetonitrile; 1: Suzuki reaction;

DOI:10.1016/j.bmcl.2006.04.061

upstream raw materials:

4-(4-bromobenzoyl)piperidine-1-carboxylic acid tert-butyl ester

Downstream raw materials:

4-[amino-(3'-cyano-biphenyl-4-yl)-methyl]-piperidine-1-carboxylic acid tert-butyl ester

4'-{[(6-chloro-5-fluoro-1H-benzoimidazol-2-ylmethyl)-amino]-piperidin-4-yl-methyl}-biphenyl-3-carbonitrile

4-[[(6-chloro-5-fluoro-1H-benzoimidazol-2-ylmethyl)-amino]-(3'-cyano-biphenyl-4-yl)-methyl]-piperidine-1-carboxylic acid tert-butyl ester