6-(AMinoMethyl)-2H-benzo[b][1,4]oxazin-3(4H)-one hydrochloride

Base Information

• Chemical Name: 6-(AMinoMethyl)-2H-benzo[b][1,4]oxazin-3(4H)-one hydrochloride
• CAS No.: 916211-06-8
• Molecular Formula: C₉H₁₀N₂O₂*ClH
• Molecular Weight: 214.652
• Mol file: 916211-06-8.mol

Synonyms:6-(aminomethyl)-2H-benzo[1,4]oxazin-3(4H)-one hydrochloride

Chemical Property of 6-(AMinoMethyl)-2H-benzo[b][1,4]oxazin-3(4H)-one hydrochloride

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

6-Aminomethyl-4H-benzo[1,4]oxazin-3-onehydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-(AMinoMethyl)-2H-benzo[b][1,4]oxazin-3(4H)-one hydrochloride

There total 3 articles about 6-(AMinoMethyl)-2H-benzo[b][1,4]oxazin-3(4H)-one hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethyl)carbamic acid tert-butyl ester (134997-81-2) → 6-(aminomethyl)-2H-benzo[1,4]oxazin-3(4H)-one hydrochloride (916211-06-8)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 3h;

DOI:10.1021/jm201152u

Reference yield:

6-chloro-2H-1,4-benzoxazin-3(4H)-one (7652-29-1) → 6-(aminomethyl)-2H-benzo[1,4]oxazin-3(4H)-one hydrochloride (916211-06-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 1-methyl-pyrrolidin-2-one / 250 °C / Inert atmosphere

2: sodium tetrahydroborate; nickel(II) chloride hexahydrate / methanol / 0.33 h / 0 - 5 °C

3: hydrogenchloride / 1,4-dioxane / 3 h / 20 °C

With hydrogenchloride; sodium tetrahydroborate; nickel(II) chloride hexahydrate; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; methanol;

DOI:10.1021/jm201152u

Reference yield:

3-oxo-3,4-dihydro-2H-benzo[1,4]oxazine-6-carbonitrile (134997-74-3) → 6-(aminomethyl)-2H-benzo[1,4]oxazin-3(4H)-one hydrochloride (916211-06-8)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium tetrahydroborate; nickel(II) chloride hexahydrate / methanol / 0.33 h / 0 - 5 °C

2: hydrogenchloride / 1,4-dioxane / 3 h / 20 °C

With hydrogenchloride; sodium tetrahydroborate; nickel(II) chloride hexahydrate; In 1,4-dioxane; methanol;

DOI:10.1021/jm201152u

upstream raw materials:

(3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethyl)carbamic acid tert-butyl ester

6-chloro-2H-1,4-benzoxazin-3(4H)-one

3-oxo-3,4-dihydro-2H-benzo[1,4]oxazine-6-carbonitrile

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