2-[2-(3,4-Dimethoxy-phenyl)-ethylamino]-cyclohex-1-enecarboxylic acid ethyl ester

Base Information

• Chemical Name: 2-[2-(3,4-Dimethoxy-phenyl)-ethylamino]-cyclohex-1-enecarboxylic acid ethyl ester
• CAS No.: 77638-67-6
• Molecular Formula: C₁₉H₂₇NO₄
• Molecular Weight: 333.428

Synonyms:2-[2-(3,4-Dimethoxy-phenyl)-ethylamino]-cyclohex-1-enecarboxylic acid ethyl ester

Chemical Property of 2-[2-(3,4-Dimethoxy-phenyl)-ethylamino]-cyclohex-1-enecarboxylic acid ethyl ester

Chemical Property:

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Technology Process of 2-[2-(3,4-Dimethoxy-phenyl)-ethylamino]-cyclohex-1-enecarboxylic acid ethyl ester

There total 1 articles about 2-[2-(3,4-Dimethoxy-phenyl)-ethylamino]-cyclohex-1-enecarboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(3,4-dimethoxyphenyl)-ethylamine (120-20-7) + ethyl 2-oxocyclohexane carboxylate (1655-07-8) → 2-[2-(3,4-Dimethoxy-phenyl)-ethylamino]-cyclohex-1-enecarboxylic acid ethyl ester (77638-67-6)

Guidance literature:

In ethanol; at 90 - 100 ℃; for 2h;

DOI:10.1248/cpb.38.1462

Reference yield: 100.0%

2-[2-(3,4-Dimethoxy-phenyl)-ethylamino]-cyclohex-1-enecarboxylic acid ethyl ester (77638-67-6) + acryloyl chloride (814-68-6,25189-84-8) → 1-[2-(3,4-dimethoxy-phenyl)-ethyl]-2-oxo-1,3,4,5,6,7-hexahydro-2H-quinoline-4a-carboxylic acid ethyl ester

Guidance literature:

In 1,4-dioxane; at 60 ℃; for 1.5h;

DOI:10.1016/S0040-4039(03)01190-0

Reference yield: 95.0%

maleic anhydride (108-31-6) + 2-[2-(3,4-Dimethoxy-phenyl)-ethylamino]-cyclohex-1-enecarboxylic acid ethyl ester (77638-67-6) → (3S,3aR)-3-Carboxymethyl-1-[2-(3,4-dimethoxy-phenyl)-ethyl]-2-oxo-1,2,3,4,5,6-hexahydro-indole-3a-carboxylic acid ethyl ester

Guidance literature:

In 1,4-dioxane; at 85 ℃; for 14h;

DOI:10.1016/S0040-4039(03)01190-0

upstream raw materials:

2-(3,4-dimethoxyphenyl)-ethylamine

ethyl 2-oxocyclohexane carboxylate

Downstream raw materials:

1-[2-(3,4-Dimethoxy-phenyl)-ethyl]-2,3-dioxo-1,2,3,4,5,6-hexahydro-indole-3a-carboxylic acid ethyl ester

1-<2-(3,4-Dimethoxyphenyl)-ethyl>-2,3-dioxo-2,3,3a,4,5,6-hexahydroindole

(3S,3aS)-1-[2-(3,4-Dimethoxy-phenyl)-ethyl]-3-hydroxy-2-oxo-1,2,3,4,5,6-hexahydro-indole-3a-carboxylic acid ethyl ester

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