5-(4-METHYLPIPERAZINO)-2-NITROBENZENECARBOXAMIDE

Base Information

• Chemical Name: 5-(4-METHYLPIPERAZINO)-2-NITROBENZENECARBOXAMIDE
• CAS No.: 383148-04-7
• Molecular Formula: C₁₂H₁₆N₄O₃
• Molecular Weight: 264.284
• Mol file: 383148-04-7.mol

Synonyms:5-(4-methylpiperazin-1-yl)-2-nitrobenzamide

Chemical Property of 5-(4-METHYLPIPERAZINO)-2-NITROBENZENECARBOXAMIDE

Chemical Property:

Purity/Quality:

5-(4-METHYLPIPERAZINO)-2-NITROBENZENECARBOXAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(4-METHYLPIPERAZINO)-2-NITROBENZENECARBOXAMIDE

There total 4 articles about 5-(4-METHYLPIPERAZINO)-2-NITROBENZENECARBOXAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

1-methyl-piperazine (109-01-3) + 2-nitro-5-fluorobenzamide (77206-97-4) → 5-(4-methylpiperazin-1-yl)-2-nitrobenzamide (383148-04-7)

Guidance literature:

With potassium carbonate; In dimethyl sulfoxide; at 60 ℃; for 1h;

DOI:10.1021/acs.jmedchem.0c01374

Reference yield:

3-fluorobenzoic acid (455-38-9) → 5-(4-methylpiperazin-1-yl)-2-nitrobenzamide (383148-04-7)

Guidance literature:

Multi-step reaction with 4 steps

1: sulfuric acid; nitric acid / 1 h / 0 - 20 °C

2: thionyl chloride / 2 h / Reflux

3: ammonia / dichloromethane

4: potassium carbonate / dimethyl sulfoxide / 1 h / 60 °C

With thionyl chloride; sulfuric acid; ammonia; nitric acid; potassium carbonate; In dichloromethane; dimethyl sulfoxide;

DOI:10.1021/acs.jmedchem.0c01374

Reference yield:

5-fluoro-2-nitrobenzoic acid (320-98-9) → 5-(4-methylpiperazin-1-yl)-2-nitrobenzamide (383148-04-7)

Guidance literature:

Multi-step reaction with 3 steps

1: thionyl chloride / 2 h / Reflux

2: ammonia / dichloromethane

3: potassium carbonate / dimethyl sulfoxide / 1 h / 60 °C

With thionyl chloride; ammonia; potassium carbonate; In dichloromethane; dimethyl sulfoxide;

DOI:10.1021/acs.jmedchem.0c01374

upstream raw materials:

1-methyl-piperazine

2-nitro-5-fluorobenzamide

3-fluorobenzoic acid

5-fluoro-2-nitrobenzoic acid

Downstream raw materials:

C₁₂H₁₈N₄O