(Z)-1-benzyl-4-(4-fluorophenyl)piperidin-3-one O-2-chlorobenzyl oxime

Base Information

• Chemical Name: (Z)-1-benzyl-4-(4-fluorophenyl)piperidin-3-one O-2-chlorobenzyl oxime
• CAS No.: 1280635-09-7
• Molecular Formula: C₂₅H₂₄ClFN₂O
• Molecular Weight: 422.93
• Mol file: 1280635-09-7.mol

Synonyms:(Z)-1-benzyl-4-(4-fluorophenyl)piperidin-3-one O-2-chlorobenzyl oxime

Chemical Property of (Z)-1-benzyl-4-(4-fluorophenyl)piperidin-3-one O-2-chlorobenzyl oxime

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (Z)-1-benzyl-4-(4-fluorophenyl)piperidin-3-one O-2-chlorobenzyl oxime

There total 1 articles about (Z)-1-benzyl-4-(4-fluorophenyl)piperidin-3-one O-2-chlorobenzyl oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

1-benzyl-4-(4-fluorophenyl)piperidin-3-one oxime (1280635-01-9) + 1-chloro-2-(chloromethyl)benzene (611-19-8) → (Z)-1-benzyl-4-(4-fluorophenyl)piperidin-3-one O-2-chlorobenzyl oxime (1280635-09-7)

Guidance literature:

1-benzyl-4-(4-fluorophenyl)piperidin-3-one oxime; With sodium hydride; In tetrahydrofuran; at 20 ℃; for 1h;

1-chloro-2-(chloromethyl)benzene; In N,N-dimethyl-formamide; at 50 ℃; for 120h;

DOI:10.1016/j.ejmech.2010.12.018

Reference yield:

(Z)-1-benzyl-4-(4-fluorophenyl)piperidin-3-one O-2-chlorobenzyl oxime (1280635-09-7) → (E)-4-(4-fluorophenyl)piperidin-3-one O-2-chlorobenzyl oxime hydrochloride (1280634-84-5) + (Z)-4-(4-fluorophenyl)piperidin-3-one O-2-chlorobenzyl oxime hydrochloride (1280634-85-6)

Guidance literature:

With hydrogenchloride; 10% palladium on activated charcoal; hydrogen; In ethanol; at 20 ℃; for 30h; under 760.051 Torr; pH=3; optical yield given as %de;

DOI:10.1016/j.ejmech.2010.12.018

upstream raw materials:

1-benzyl-4-(4-fluorophenyl)piperidin-3-one oxime

1-chloro-2-(chloromethyl)benzene

Downstream raw materials:

(E)-4-(4-fluorophenyl)piperidin-3-one O-2-chlorobenzyl oxime hydrochloride

(Z)-4-(4-fluorophenyl)piperidin-3-one O-2-chlorobenzyl oxime hydrochloride