5-bromo-8-benzyloxy-1-(3,4-dimethoxybenzyl)-7-methoxy-3,4-dihydroisoquinoline

Base Information

Chemical Name:5-bromo-8-benzyloxy-1-(3,4-dimethoxybenzyl)-7-methoxy-3,4-dihydroisoquinoline
CAS No.:160857-66-9
Molecular Formula:C₂₆H₂₆BrNO₄
Molecular Weight:496.401
Hs Code.:

Synonyms:5-bromo-8-benzyloxy-1-(3,4-dimethoxybenzyl)-7-methoxy-3,4-dihydroisoquinoline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-bromo-8-benzyloxy-1-(3,4-dimethoxybenzyl)-7-methoxy-3,4-dihydroisoquinoline

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Technology Process of 5-bromo-8-benzyloxy-1-(3,4-dimethoxybenzyl)-7-methoxy-3,4-dihydroisoquinoline

There total 10 articles about 5-bromo-8-benzyloxy-1-(3,4-dimethoxybenzyl)-7-methoxy-3,4-dihydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 129913-14-0
(3,4-dimethoxyphenyl)ketene

: 160857-70-5
(3-benzyloxy-6-bromo-4-methoxyphenethylimino)triphenylphosphorane

: 160857-66-9
5-bromo-8-benzyloxy-1-(3,4-dimethoxybenzyl)-7-methoxy-3,4-dihydroisoquinoline

Guidance literature:: In toluene; 0 deg C, 2 h then 75 deg C, 14 h;
DOI:10.1016/0040-4039(94)02211-S

Reference yield:

: 141035-23-6
5-Benzyloxy-2-brom-4-methoxy-phenaethylamin

: 160857-66-9
5-bromo-8-benzyloxy-1-(3,4-dimethoxybenzyl)-7-methoxy-3,4-dihydroisoquinoline

Guidance literature:: Multi-step reaction with 3 steps

1: 79 percent / CCl₄ / CH₂Cl₂ / 72 h / 40 °C

2: 95 percent / sodium amide / toluene / 1 h / 100 °C

3: 76 percent / toluene / 14 h / 75 °C

With tetrachloromethane; sodium amide; In dichloromethane; toluene; 3: aza-Wittig reaction;
DOI:10.1021/jo030287t

Reference yield:

: 25349-38-6
4-[(E)-(3,4-dimethoxyphenyl)methylidene]-2-phenyl-1,3-oxazol-5(4H)-one

: 160857-66-9
5-bromo-8-benzyloxy-1-(3,4-dimethoxybenzyl)-7-methoxy-3,4-dihydroisoquinoline

Guidance literature:: Multi-step reaction with 3 steps

1.1: NaOH / 90 °C

1.2: 83 percent / H₂O₂

2.1: 78 percent / dicyclohexylcarbodiimide; Et₃N / tetrahydrofuran / 2 h / 0 °C

3.1: 76 percent / toluene / 14 h / 75 °C

With sodium hydroxide; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; toluene; 3.1: aza-Wittig reaction;
DOI:10.1021/jo030287t