(2S,6R)-2-[(2R,5S,8S)-8,10-bis-(tert-butyldimethylsilanyloxy)-2-methoxy-5-methyl-4-methylenedecyl]-6-[2-(4-methoxybenzyloxy)ethyl]-4-methylenetetrahydropyran

Base Information

Chemical Name:(2S,6R)-2-[(2R,5S,8S)-8,10-bis-(tert-butyldimethylsilanyloxy)-2-methoxy-5-methyl-4-methylenedecyl]-6-[2-(4-methoxybenzyloxy)ethyl]-4-methylenetetrahydropyran
CAS No.:617715-09-0
Molecular Formula:C₄₁H₇₄O₆Si₂
Molecular Weight:719.206
Hs Code.:

(2S,6R)-2-[(2R,5S,8S)-8,10-bis-(tert-butyldimethylsilanyloxy)-2-methoxy-5-methyl-4-methylenedecyl]-6-[2-(4-methoxybenzyloxy)ethyl]-4-methylenetetrahydropyran

Synonyms:(2S,6R)-2-[(2R,5S,8S)-8,10-bis-(tert-butyldimethylsilanyloxy)-2-methoxy-5-methyl-4-methylenedecyl]-6-[2-(4-methoxybenzyloxy)ethyl]-4-methylenetetrahydropyran

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Chemical Property of (2S,6R)-2-[(2R,5S,8S)-8,10-bis-(tert-butyldimethylsilanyloxy)-2-methoxy-5-methyl-4-methylenedecyl]-6-[2-(4-methoxybenzyloxy)ethyl]-4-methylenetetrahydropyran

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Technology Process of (2S,6R)-2-[(2R,5S,8S)-8,10-bis-(tert-butyldimethylsilanyloxy)-2-methoxy-5-methyl-4-methylenedecyl]-6-[2-(4-methoxybenzyloxy)ethyl]-4-methylenetetrahydropyran

There total 8 articles about (2S,6R)-2-[(2R,5S,8S)-8,10-bis-(tert-butyldimethylsilanyloxy)-2-methoxy-5-methyl-4-methylenedecyl]-6-[2-(4-methoxybenzyloxy)ethyl]-4-methylenetetrahydropyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 420-37-1
trimethoxonium tetrafluoroborate

: 617714-96-2
(2R,5S,8S)-8,10-bis(tert-butyldimethylsilyloxy)-1-((2S,6R)-6-(2-(4-methoxybenzyloxy)ethyl)-4-methylenetetrahydro-2H-pyran-2-yl)-5-methyl-4-methylenedecan-2-ol

: 617715-09-0
(2S,6R)-2-[(2R,5S,8S)-8,10-bis-(tert-butyldimethylsilanyloxy)-2-methoxy-5-methyl-4-methylenedecyl]-6-[2-(4-methoxybenzyloxy)ethyl]-4-methylenetetrahydropyran

Guidance literature:: With Proton Sponge; 4 A molecular sieve; In dichloromethane;
DOI:10.1002/anie.200351817

Reference yield:

: 617714-87-1
((2S,6R)-6-[2-(4-methoxybenzyloxy)ethyl]-4-methylenetetrahydropyran-2-yl)-acetaldehyde

: 617715-09-0
(2S,6R)-2-[(2R,5S,8S)-8,10-bis-(tert-butyldimethylsilanyloxy)-2-methoxy-5-methyl-4-methylenedecyl]-6-[2-(4-methoxybenzyloxy)ethyl]-4-methylenetetrahydropyran

Guidance literature:: Multi-step reaction with 2 steps

1.1: (R,R)-1,2-diamino-1,2-diphenylethane bis(sulfonamide); boron tribromide / CH₂Cl₂ / 10 h / 20 °C

1.2: CH₂Cl₂ / 1.5 h / -78 °C

2.1: 96 percent / proton sponge; 4-Angstroem molecular sieves / CH₂Cl₂

With Proton Sponge; (R,R)-1,2-diamino-1,2-diphenylethane bis(sulfonamide); 4 A molecular sieve; boron tribromide; In dichloromethane;
DOI:10.1002/anie.200351817

Reference yield:

: 617715-06-7
(2S,6R)-2-[1,3]dithian-2-ylmethyl-6-[2-(4-methoxybenzyloxy)ethyl]-4-methylenetetrahydropyran

: 617715-09-0
(2S,6R)-2-[(2R,5S,8S)-8,10-bis-(tert-butyldimethylsilanyloxy)-2-methoxy-5-methyl-4-methylenedecyl]-6-[2-(4-methoxybenzyloxy)ethyl]-4-methylenetetrahydropyran

Guidance literature:: Multi-step reaction with 3 steps

1.1: 100 percent / MeI; CaCO₃; H₂O / acetonitrile / 16 h

2.1: (R,R)-1,2-diamino-1,2-diphenylethane bis(sulfonamide); boron tribromide / CH₂Cl₂ / 10 h / 20 °C

2.2: CH₂Cl₂ / 1.5 h / -78 °C

3.1: 96 percent / proton sponge; 4-Angstroem molecular sieves / CH₂Cl₂

With Proton Sponge; (R,R)-1,2-diamino-1,2-diphenylethane bis(sulfonamide); 4 A molecular sieve; water; boron tribromide; calcium carbonate; methyl iodide; In dichloromethane; acetonitrile;
DOI:10.1002/anie.200351817