3-[4-(1-trityl-1H-imidazol-4-ylmethyl)-piperidin-1-yl]-propan-1-ol

Base Information

• Chemical Name: 3-[4-(1-trityl-1H-imidazol-4-ylmethyl)-piperidin-1-yl]-propan-1-ol
• CAS No.: 877142-02-4
• Molecular Formula: C₃₁H₃₅N₃O
• Molecular Weight: 465.638
• Mol file: 877142-02-4.mol

Synonyms:3-[4-(1-trityl-1H-imidazol-4-ylmethyl)-piperidin-1-yl]-propan-1-ol

Chemical Property of 3-[4-(1-trityl-1H-imidazol-4-ylmethyl)-piperidin-1-yl]-propan-1-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-[4-(1-trityl-1H-imidazol-4-ylmethyl)-piperidin-1-yl]-propan-1-ol

There total 6 articles about 3-[4-(1-trityl-1H-imidazol-4-ylmethyl)-piperidin-1-yl]-propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

acetic acid pyridin-4-yl-(1-trityl-1H-imidazol-4-yl)-methyl ester (224168-76-7) → 3-[4-(1-trityl-1H-imidazol-4-ylmethyl)-piperidin-1-yl]-propan-1-ol (877142-02-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 96 percent / H₂; AcOH / PtO₂ / 3102.89 Torr

2: methanol

3: LiAlH₄ / tetrahydrofuran

With lithium aluminium tetrahydride; hydrogen; acetic acid; platinum(IV) oxide; In tetrahydrofuran; methanol;

DOI:10.1016/j.bmcl.2005.09.076

Reference yield:

pyridine-4-carbaldehyde (872-85-5) → 3-[4-(1-trityl-1H-imidazol-4-ylmethyl)-piperidin-1-yl]-propan-1-ol (877142-02-4)

Guidance literature:

Multi-step reaction with 5 steps

1.1: CH₂Cl₂

1.2: 100 percent / CH₂Cl₂

2.1: 85 percent / DMAP / CH₂Cl₂

3.1: 96 percent / H₂; AcOH / PtO₂ / 3102.89 Torr

4.1: methanol

5.1: LiAlH₄ / tetrahydrofuran

With dmap; lithium aluminium tetrahydride; hydrogen; acetic acid; platinum(IV) oxide; In tetrahydrofuran; methanol; dichloromethane;

DOI:10.1016/j.bmcl.2005.09.076

Reference yield:

N-trityl-4(5)-iodoimidazole (96797-15-8) → 3-[4-(1-trityl-1H-imidazol-4-ylmethyl)-piperidin-1-yl]-propan-1-ol (877142-02-4)

Guidance literature:

Multi-step reaction with 5 steps

1.1: CH₂Cl₂

1.2: 100 percent / CH₂Cl₂

2.1: 85 percent / DMAP / CH₂Cl₂

3.1: 96 percent / H₂; AcOH / PtO₂ / 3102.89 Torr

4.1: methanol

5.1: LiAlH₄ / tetrahydrofuran

With dmap; lithium aluminium tetrahydride; hydrogen; acetic acid; platinum(IV) oxide; In tetrahydrofuran; methanol; dichloromethane;

DOI:10.1016/j.bmcl.2005.09.076

upstream raw materials:

3-[4-(1-trityl-1H-imidazol-4-ylmethyl)-piperidin-1-yl]-propionic acid methyl ester

acetic acid pyridin-4-yl-(1-trityl-1H-imidazol-4-yl)-methyl ester

4-(1-trityl-1H-imidazol-4-ylmethyl)-piperidine

pyridine-4-carbaldehyde

Downstream raw materials:

3-(4-{3-[4-(1-trityl-1H-imidazol-4-ylmethyl)-piperidin-1-yl]-propoxy}-phenyl)-pyridine

1-[3-(4-Piperidin-1-ylmethyl-phenoxy)-propyl]-4-(1-trityl-1H-imidazol-4-ylmethyl)-piperidine

1-[3-(3-Piperidin-1-ylmethyl-phenoxy)-propyl]-4-(1-trityl-1H-imidazol-4-ylmethyl)-piperidine

1-[3-(4-cyclohexyloxy-phenoxy)-propyl]-4-(1-trityl-1H-imidazol-4-ylmethyl)-piperidine