1-benzyl-4-(chloromethyl)-2-cyclohexyl-1H-imidazole

Base Information

Chemical Name:1-benzyl-4-(chloromethyl)-2-cyclohexyl-1H-imidazole
CAS No.:1452819-58-7
Molecular Formula:C₁₇H₂₁ClN₂
Molecular Weight:288.82
Hs Code.:

Synonyms:1-benzyl-4-(chloromethyl)-2-cyclohexyl-1H-imidazole

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Chemical Property of 1-benzyl-4-(chloromethyl)-2-cyclohexyl-1H-imidazole

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Technology Process of 1-benzyl-4-(chloromethyl)-2-cyclohexyl-1H-imidazole

There total 7 articles about 1-benzyl-4-(chloromethyl)-2-cyclohexyl-1H-imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1452819-55-4
(1-benzyl-2-cyclohexyl-1H-imidazol-4-yl)methanol

: 1452819-58-7
1-benzyl-4-(chloromethyl)-2-cyclohexyl-1H-imidazole

Guidance literature:: With thionyl chloride; at 25 ℃; for 3h; Inert atmosphere;
DOI:10.1002/ejoc.201201467

Reference yield:

: 2043-61-0
cyclohexanecarbaldehyde

: 1452819-58-7
1-benzyl-4-(chloromethyl)-2-cyclohexyl-1H-imidazole

Guidance literature:: Multi-step reaction with 7 steps

1.1: ammonium bicarbonate / water / 18 h / 25 °C / Inert atmosphere

2.1: triethylamine / dichloromethane / 14 h / 25 °C / Inert atmosphere

3.1: n-butyllithium / tetrahydrofuran; hexane / 1.42 h / -78 °C / Inert atmosphere

3.2: 3 h / -78 - 25 °C / Inert atmosphere

4.1: hydrogenchloride / water / 2 h / 25 °C / Inert atmosphere

5.1: caesium carbonate / N,N-dimethyl-formamide / 14.5 h / 0 - 25 °C / Inert atmosphere

6.1: sodium tetrahydroborate / methanol / 3 h / 0 - 25 °C / Inert atmosphere

7.1: thionyl chloride / 3 h / 25 °C / Inert atmosphere

With hydrogenchloride; sodium tetrahydroborate; n-butyllithium; thionyl chloride; ammonium bicarbonate; caesium carbonate; triethylamine; In tetrahydrofuran; methanol; hexane; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1002/ejoc.201201467

Reference yield:

: 14085-43-9
2-cyclohexyl-1H-imidazole

: 1452819-58-7
1-benzyl-4-(chloromethyl)-2-cyclohexyl-1H-imidazole

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine / dichloromethane / 14 h / 25 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran; hexane / 1.42 h / -78 °C / Inert atmosphere

2.2: 3 h / -78 - 25 °C / Inert atmosphere

3.1: hydrogenchloride / water / 2 h / 25 °C / Inert atmosphere

4.1: caesium carbonate / N,N-dimethyl-formamide / 14.5 h / 0 - 25 °C / Inert atmosphere

5.1: sodium tetrahydroborate / methanol / 3 h / 0 - 25 °C / Inert atmosphere

6.1: thionyl chloride / 3 h / 25 °C / Inert atmosphere

With hydrogenchloride; sodium tetrahydroborate; n-butyllithium; thionyl chloride; caesium carbonate; triethylamine; In tetrahydrofuran; methanol; hexane; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1002/ejoc.201201467