(2aR,3R,4R,5aR)-3-benzyloxy-4-fluorocyclopentanoisoxazolidine

Base Information

Chemical Name:(2aR,3R,4R,5aR)-3-benzyloxy-4-fluorocyclopentanoisoxazolidine
CAS No.:160332-09-2
Molecular Formula:C₁₃H₁₆FNO₂
Molecular Weight:237.274
Hs Code.:

(2aR,3R,4R,5aR)-3-benzyloxy-4-fluorocyclopentano<c>isoxazolidine

Synonyms:(2aR,3R,4R,5aR)-3-benzyloxy-4-fluorocyclopentanoisoxazolidine

Suppliers and Price of (2aR,3R,4R,5aR)-3-benzyloxy-4-fluorocyclopentanoisoxazolidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 1 raw suppliers

Chemical Property of (2aR,3R,4R,5aR)-3-benzyloxy-4-fluorocyclopentanoisoxazolidine

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

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Technology Process of (2aR,3R,4R,5aR)-3-benzyloxy-4-fluorocyclopentanoisoxazolidine

There total 2 articles about (2aR,3R,4R,5aR)-3-benzyloxy-4-fluorocyclopentanoisoxazolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 160332-05-8
(3R,4R,5aR)-3-benzyloxy-4-fluorocyclopentano2-isoxazoline

: 160332-09-2
(2aR,3R,4R,5aR)-3-benzyloxy-4-fluorocyclopentanoisoxazolidine

Guidance literature:: With hydrogenchloride; sodium cyanoborohydride; In methanol; for 3h;
DOI:10.1016/0957-4166(94)80052-9

Reference yield:

: (2R,3R)-2-benzyloxy-3-fluoro-5-hexenal oxime

: 160332-09-2
(2aR,3R,4R,5aR)-3-benzyloxy-4-fluorocyclopentanoisoxazolidine

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hypochlorite, Et₃N / CH₂Cl₂ / Ambient temperature

2: 94 percent / aq. HCl, NaBH₃CN / methanol / 3 h

With hydrogenchloride; sodium hypochlorite; sodium cyanoborohydride; triethylamine; In methanol; dichloromethane;
DOI:10.1016/0957-4166(94)80052-9

Reference yield: 78.0%

: 160332-09-2
(2aR,3R,4R,5aR)-3-benzyloxy-4-fluorocyclopentanoisoxazolidine

: 160189-50-4,160332-08-1
(2aR,3R,4R,5aR)-3-hydroxy-4-fluorocyclopentanoisoxazolidine

Guidance literature:: With hydrogen; trifluoroacetic acid; palladium on activated charcoal; for 8h; under 1034.3 Torr;
DOI:10.1016/0957-4166(94)80052-9